Details of the Drug Combinations

General Information of This Drug (ID: DM4XMF7)

Drug Name

LY2606368 DM4XMF7

Synonyms

prexasertib; Prexasertib; 1234015-52-1; UNII-820NH671E6; LY-2606368; 820NH671E6; Prexasertib [USAN]; 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile; 5-({5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl}amino)pyrazine-2-carbonitrile; 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile; SCHEMBL1975451; GTPL9549; SCHEMBL19457660; SCHEMBL18989301; CHEMBL3544911; EX-A758; DOTGPNHGTYJDEP-UHFFFAOYSA-N; AOB87325; ZINC95837013

Indication

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Phase 2	[1]
Small-cell lung cancer	2C25.Y	Phase 2	[1]
Head and neck cancer	2D42	Phase 1	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
Squamous cell anal carcinoma	2C00.3	Phase 1	[3]
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Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Cyclophosphamide + LY2606368	DCHZGHS	Cyclophosphamide	Brain Tumor	[4]
LY2606368 + Irinotecan	DC510NS	Irinotecan	Desmoplastic Small Round Cell Tumor	[5]
LY2606368 + LY-2228820	DCA6O5U	LY-2228820	Advanced Cancer	[6]
LY2606368 + Gemcitabine	DCKP9JQ	Gemcitabine	Brain Tumor	[4]
LY2606368 + Olaparib	DCOJ8Y8	Olaparib	Solid Tumor	[7]
LY2606368 + Pemetrexed	DCRTKMR	Pemetrexed	Neoplasm Metastasis	[8]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Clinical pipeline report, company report or official report of Eli Lilly.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	ClinicalTrials.gov (NCT04023669) Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors
5	ClinicalTrials.gov (NCT04095221) A Study of the Drugs Prexasertib, Irinotecan, and Temozolomide in People With Desmoplastic Small Round Cell Tumor and Rhabdomyosarcoma
6	ClinicalTrials.gov (NCT02860780) A Study of Prexasertib (LY2606368) in Combination With Ralimetinib in Participants With Advanced or Metastatic Cancer
7	ClinicalTrials.gov (NCT03057145) Combination Study of Prexasertib and Olaparib in Patients With Advanced Solid Tumors
8	ClinicalTrials.gov (NCT02124148) A Study of Prexasertib (LY2606368) With Chemotherapy or Targeted Agents in Participants With Advanced Cancer