Details of the Drug Combinations

General Information of This Drug (ID: DM4YDAJ)

• Drug Name: Sildenafil (DM4YDAJ)
• Synonyms: sildenafil; 139755-83-2; VIAGRA; Sildenafil [INN:BAN]; UK-92480; UNII-3M7OB98Y7H; UK-92,480-10; C22H30N6O4S; HSDB 7305; CHEMBL192; UK 92480-10; CHEBI:9139; 3M7OB98Y7H; BNRNXUUZRGQAQC-UHFFFAOYSA-N; Sildenafil

Indication

Alveolar capillary dysplasia with misalignment of pulmonary veins; ICD 11: N.A.; Status: Approved [1]; Erectile dysfunction; ICD 11: HA01.1; Status: Approved [2]; Coronavirus Disease 2019 (COVID-19); ICD 11: 1D6Y; Status: Phase 3 [3]; Respiratory failure; ICD 11: CB41; Status: Investigative [1]

• Therapeutic Class: Antiviral Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

15 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Sildenafil + Bosentan	DCZ1DCR	Bosentan	Persistent Pulmonary Hypertension of the Newborn	[4]
Sildenafil + Testosterone	DC1ZD7V	Testosterone	Hypoactive Sexual Desire Disorder	[5]
Sildenafil + Sitaxsentan	DC3P4O2	Sitaxsentan	Pulmonary Arterial Hypertension	[6]
Sildenafil + Saxagliptin	DC3X8FD	Saxagliptin	Diabetes Mellitus, Type 2	[7]
Sildenafil + Riociguat	DC523Z8	Riociguat	Pulmonary Hypertension	[8]
Sildenafil + Bosentan	DC70BCK	Bosentan	Pulmonary Arterial Hypertension	[9]
Sildenafil + Tadalafil	DCLWWW5	Tadalafil	Erectile Dysfunction	[10]
Sildenafil + Milrinone	DC4TVFH	Milrinone	Pulmonary Hypertension	[11]
Sildenafil + Acetylcholine	DCDR4AC	Acetylcholine	Microvascular Coronary Artery Disease	[12]
Sildenafil + Pirfenidone	DCJOTCU	Pirfenidone	Idiopathic Pulmonary Fibrosis	[13]
Sildenafil + Bosentan	DCBTMZ7	Bosentan	Pulmonary Hypertension	[14]
Sildenafil + Bosentan	DCE3E40	Bosentan	Pulmonary Arterial Hypertension	[15]
Sildenafil + Nintedanib	DCBV8KL	Nintedanib	Idiopathic Pulmonary Fibrosis	[16]
Sildenafil + Ambrisentan	DCH9H5Q	Ambrisentan	Pulmonary Arterial Hypertension	[17]
Sildenafil + Tramadol	DCTYZ84	Tramadol	Premature Ejaculation	[18]

References

• [1] Sildenafil FDA Label
• [2] FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 206401.
• [3] ClinicalTrials.gov (NCT04304313) A Pilot Study of Sildenafil in COVID-19. U.S. National Institutes of Health.
• [4] ClinicalTrials.gov (NCT04379180) Population Pharmacokinetics and Dosage Individualization of Oral Pulmonary Vasodilators in PPHN
• [5] ClinicalTrials.gov (NCT01432665) Lybrido for Female Sexual Dysfunction
• [6] ClinicalTrials.gov (NCT01244620) A Pharmacokinetic Drug-Drug Interaction (DDI) Study Between Sitaxsentan And Sildenafil, And Between Sitaxsentan And Tadalafil After Multiple Doses
• [7] ClinicalTrials.gov (NCT04170790) Evaluation of Drug Interactions of Saxagliptin With Sildenafil in Healthy Volunteers
• [8] ClinicalTrials.gov (NCT01179334) Evaluation of the Pharmacodynamic Effect of the Combination of Sildenafil and Riociguat on Blood Pressure and Other Safety Parameters.
• [9] ClinicalTrials.gov (NCT00433329) Combination Therapy in Pulmonary Arterial Hypertension
• [10] ClinicalTrials.gov (NCT01352507) A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China
• [11] ClinicalTrials.gov (NCT02595541) Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary Hypertension
• [12] ClinicalTrials.gov (NCT03462017) Pharmacodynamic Study to Assess the Effects of Repeated Dosing of SAR247799 on Endothelial Function in Patients With Type 2 Diabetes Mellitus
• [13] ClinicalTrials.gov (NCT02951429) Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Intermediate or High Probability of Group 3 Pulmonary Hypertension
• [14] ClinicalTrials.gov (NCT00302211) The "VISION" Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension
• [15] ClinicalTrials.gov (NCT01392469) Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension Participants
• [16] ClinicalTrials.gov (NCT02802345) Efficacy and Safety of Nintedanib Co-administered With Sildenafil in Idiopathic Pulmonary Fibrosis Patients With Advanced Lung Function Impairment
• [17] ClinicalTrials.gov (NCT00617305) Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy in Pulmonary Arterial Hypertension (ATHENA-1)
• [18] ClinicalTrials.gov (NCT05183334) Combined On-demand Sildenafil Citrate and Tramadol Hydrochloride for Treatment of Premature Ejaculation