Details of the Drug Combinations

General Information of This Drug (ID: DM53SRA)

Drug Name

Prochlorperazine DM53SRA

Synonyms

CHLOPERAZINE; Capazine; Chlormeprazine; Chlorperazine; Combid; Compazine; Compro; Emelent; Eskatrol; Kronocin; Meterazin; Meterazine; Nipodal; Novamin; Prochloroperazine; Prochlorpemazine; Prochlorperazin; Prochlorperazinum; Prochlorpermazine; Prochlorpromazine; Procloperazine; Proclorperazina; Proclorperazine; Stemetil; Tementil; Temetid; Vertigon; Compazine Suppositories; Prochlorperazine Edisylate Salt; Prochlorperazine dihydrobromide; Prochlorperazine dimaleate; Prochlorperazine maleate; Prochlorperazine mesilate; Bayer A 173; P77; RP 6140; SKF 4657; Buccastem (TN); Compazine (TN); Compro (TN); Phenotil (TN); Prochlorperazinum [INN-Latin]; Proclorperazina [INN-Spanish]; Stemetil (TN); Stemzine (TN); Compazine (*Maleate*); Prochlorperazine (JAN/USP/INN); Prochlorperazine [USAN:INN:BAN:JAN]; Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine; Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine [French]; N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine; 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine; 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10H-phenothiazine; 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine; 2-Chloro-10-[3-(4-methyl-1-piper-azinyl)propyl]-10H-pheno-thiazine dimaleate; 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine; 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine; 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine; 3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine; 6140 RP

Indication

Disease Entry	ICD 11	Status	REF
Nausea	MD90	Approved	[1]
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Therapeutic Class

Antipsychotic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

21 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Abexinostat + Prochlorperazine	DCU3IRF	Abexinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Afatinib + Prochlorperazine	DCH5SIZ	Afatinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Bardoxolone methyl + Prochlorperazine	DCTZCNH	Bardoxolone methyl	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Bardoxolone methyl + Prochlorperazine	DC1EFIH	Bardoxolone methyl	Primitive neuroectodermal tumor (Cell Line: TC-32)	[2]
Birinapant + Prochlorperazine	DCMRJAY	Birinapant	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Citarinostat + Prochlorperazine	DCL4PHV	Citarinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Panobinostat + Prochlorperazine	DCYCQVL	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
PD-0325901 + Prochlorperazine	DCV5PRI	PD-0325901	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
PD-0325901 + Prochlorperazine	DCVPAAL	PD-0325901	Primitive neuroectodermal tumor (Cell Line: TC-32)	[2]
Prochlorperazine + Buparlisib	DCDSFFX	Buparlisib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Prochlorperazine + JQ1	DC4LO0V	JQ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Prochlorperazine + RTB101	DCSCEL7	RTB101	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Prochlorperazine + Marimastat	DCBZGOR	Marimastat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Prochlorperazine + Gemcitabine	DCWNFG6	Gemcitabine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Prochlorperazine + Tamoxifen	DCS1M17	Tamoxifen	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Prochlorperazine + Tamoxifen	DCFEFED	Tamoxifen	Primitive neuroectodermal tumor (Cell Line: TC-32)	[2]
Prochlorperazine + Ciclopirox	DCJXF5R	Ciclopirox	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Prochlorperazine + Prazosin	DCPGKYD	Prazosin	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Prochlorperazine + PF-562271	DC27Z5B	PF-562271	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Prochlorperazine + CB3304	DCQBFVR	CB3304	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Prochlorperazine + E7820	DCBKASB	E7820	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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⏷ Show the Full List of 21 DrugCom(s)

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Prochlorperazine + Ketorolac	DC9DCHC	Ketorolac	Migraine	[3]
Prochlorperazine + Prochlorperazine	DCZE5I7	Prochlorperazine	Migraine	[4]
Prochlorperazine + Ketorolac	DCCCD3W	Ketorolac	Headache, Migraine	[5]
Prochlorperazine + Diphenhydramine	DCTCT3A	Diphenhydramine	Migraine	[6]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7279).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	ClinicalTrials.gov (NCT06182098) Intravenous Fluids in Pediatric Migraine
4	ClinicalTrials.gov (NCT00610727) Staccato Prochlorperazine Single Dose PK Study
5	ClinicalTrials.gov (NCT06083571) Intranasal Ketorolac Trial
6	ClinicalTrials.gov (NCT02389829) Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine