Details of the Drug Combinations

General Information of This Drug (ID: DM5J64S)

Drug Name
Miglustat   DM5J64S
Synonyms
BuDNJ; Butyldeoxynojirimycin; Miglustatum; NBV; Vevesca; Zavesca; Miglustat [USAN]; OGT 918; SC 48334; SC48334; Miglustat, Hydrochloride; N-Butyl deoxynojirimycin; N-Butyl dnj; N-Butyldeoxynojirimycin; N-Butylmoranoline; NB-DNJ; OGT-918; SC-48334; Zavesca (TN); Miglustat (USAN/INN); N-Bu-DNJ; N-Butyl-DNJ; N-Butyl-deoxynojirimycin; N-(n-Butyl)deoxynojirimycin; N-butyl-1-deoxynojirimycin; N-(n-butyl)-1,5-dideoxy-1,5-imino-D-glucitol; (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Dideoxy-1,5-N-butylimino-D-glucitol
Indication
Disease Entry ICD 11 Status REF
Niemann-Pick disease type C N.A. Approved [1]
Type 1 gaucher disease 5C56.0Y Approved [2]
Gaucher disease 5C56.0Y Investigative [1]
Therapeutic Class
Anti-HIV Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

65 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Miglustat DCSALEU Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Aprepitant + Miglustat DCI6RFE Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Atenolol + Miglustat DCDSDFJ Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Auranofin + Miglustat DCM6WXG Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Miglustat DCNOTRJ Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Miglustat DCLBVZ2 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorzoxazone + Miglustat DCUE6QY Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diazoxide + Miglustat DCWW97T Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dichlorphenamide + Miglustat DCFO95H Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dihydroergotamine + Miglustat DCB34Q9 Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diphenidol + Miglustat DCTCTU9 Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Docetaxel + Miglustat DCSD4VO Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Etomidate + Miglustat DCJDMY4 Etomidate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Gefitinib + Miglustat DCK40AX Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hyodeoxycholic acid + Miglustat DCT0OAJ Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
K-134 + Miglustat DC8CF53 K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Levamisole + Miglustat DCKCKM9 Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maprotiline + Miglustat DCPQT5F Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mebutamate + Miglustat DCWC0YK Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mesalazine + Miglustat DCAN2O6 Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methylene blue + Miglustat DC1O9J1 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Meclofenamic acid DCD3XKS Meclofenamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Ribavirin-TP DC9W9C7 Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Epinephrine DCXUCDL Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Tindamax DC4MYYC Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Vinblastine DC9UL4Q Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Anamorelin DCK4AL5 Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Fomepizole DCHYA2S Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Triapine DCVMQAD Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Pepstatin DCJR1P3 Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + IT-141 DCU0JZC IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Metyrosine DCO8C7O Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Efavirenz DCC2ADD Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Testosterone cypionate DCTLX8X Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Ginsenoside Rb1 DCUX955 Ginsenoside Rb1 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Phensuximide DCG808H Phensuximide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + PF-02545920 DC64O6S PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Norcisapride DCZ2HJA Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Idarubicin DCI53LJ Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Topotecan DC8DJTV Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Clascoterone DCH0KB7 Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Dopamine DCK5KA9 Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Oxyphenbutazone DCS59SE Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Acetohexamide DCO73WU Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Ethambutol DCFTL8Z Ethambutol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Leflunomide DC61CVB Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Asenapine DCU1RD6 Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Mycophenolic acid DCZWON2 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Mefloquine DC07YUW Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Vorinostat DCQVPNQ Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Aciclovir DCYTT30 Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Cilostazol DCNC0M6 Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mycophenolic acid + Miglustat DCYLJWY Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Nabilone + Miglustat DCPC29P Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Niclosamide + Miglustat DC9CFRE Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Palonosetron + Miglustat DC3Z9WO Palonosetron Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PMID28460551-Compound-2 + Miglustat DCBU9MA PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pramipexole + Miglustat DCE7L3V Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Procarbazine + Miglustat DCLMWWX Procarbazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sertraline + Miglustat DCO6CTL Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sitagliptin + Miglustat DCTQWJQ Sitagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sorafenib + Miglustat DCL6B9G Sorafenib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tetracycline + Miglustat DCMRYIR Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Theophylline + Miglustat DCMR7TH Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
WAY-100635 + Miglustat DCBY9TU WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 65 DrugCom(s)

References

1 Miglustat FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4841).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.