Details of the Drug Combinations

General Information of This Drug (ID: DM5Q1W4)

Drug Name
YM155   DM5Q1W4
Synonyms Sepantronium
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Non-hodgkin lymphoma 2B33.5 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

34 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-263 + Ym155 DC2GBKX ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
Artemisinin + Ym155 DCO9EOF Artemisinin DD2 (Cell Line: DD2) [3]
Artemisinin + Ym155 DCNZMUQ Artemisinin Hepatoblastoma (Cell Line: HB3) [3]
AS602868 + Ym155 DCMHEUA AS602868 Hodgkin lymphoma (Cell Line: L-1236) [2]
Bardoxolone methyl + Ym155 DCTJQCS Bardoxolone methyl Hodgkin lymphoma (Cell Line: L-1236) [3]
CA4P + Ym155 DCAJJ87 CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Cantharidin + Ym155 DCQTLP0 Cantharidin Ewing sarcoma (Cell Line: TC-71) [3]
CUDC-101 + Ym155 DC99F03 CUDC-101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Doxorubicin + Ym155 DCO6TN1 Doxorubicin Hodgkin lymphoma (Cell Line: L-1236) [3]
GDC-0084 + Ym155 DCMIBJB GDC-0084 Hodgkin lymphoma (Cell Line: L-1236) [2]
IMD-0354 + Ym155 DCPS156 IMD-0354 Hodgkin lymphoma (Cell Line: L-1236) [2]
MLN8237 + Ym155 DCZQ7BN MLN8237 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Panobinostat + Ym155 DC9CEJX Panobinostat Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Pelitinib + Ym155 DC0I46N Pelitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
PF-04691502 + Ym155 DCWEZCW PF-04691502 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
RAF265 + Ym155 DCHBKBZ RAF265 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Trametinib + Ym155 DCWNE8O Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Vincristine + Ym155 DCNELSS Vincristine Hodgkin lymphoma (Cell Line: L-1236) [3]
Ym155 + Gefitinib DC0UTUD Gefitinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Ym155 + PD-0325901 DCL0K7K PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Ym155 + AT13387 DCBNZPM AT13387 Ewing sarcoma (Cell Line: TC-71) [3]
Ym155 + LY335979 DC5GUE9 LY335979 Human papillomavirus-related cervical adenocarcinoma (Cell Line: KB-ChR-8-5-11) [3]
Ym155 + Dactinomycin DCJ4BSA Dactinomycin Hodgkin lymphoma (Cell Line: L-1236) [3]
Ym155 + Everolimus DC1POCJ Everolimus Ewing sarcoma (Cell Line: TC-71) [3]
Ym155 + THAPSIGARGIN DCGESH1 THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Ym155 + Mitomycin DC4G0DC Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [3]
Ym155 + Niclosamide DC6LQLY Niclosamide Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Ym155 + GSK618334 DCPNIZO GSK618334 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Ym155 + Tamoxifen DCMRB5Y Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Ym155 + Romidepsin DCJW4EK Romidepsin Ewing sarcoma (Cell Line: TC-71) [3]
Ym155 + Mitotane DCJ867N Mitotane Ewing sarcoma (Cell Line: TC-71) [3]
Ym155 + CYTISINE DCZGXXI CYTISINE Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Ym155 + Elacridar DC95U06 Elacridar Human papillomavirus-related cervical adenocarcinoma (Cell Line: KB-ChR-8-5-11) [3]
Ym155 + LY2874455 DCC8XGE LY2874455 Ewing sarcoma (Cell Line: TC-71) [3]
------------------------------------------------------------------------------------
⏷ Show the Full List of 34 DrugCom(s)

References

1 ClinicalTrials.gov (NCT00818480) An Extension Study Administering YM155 to Subjects Previously Enrolled in Another Protocol Administering YM155. U.S. National Institutes of Health.
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.