Details of the Drug Combinations

General Information of This Drug (ID: DM5UGDK)

Drug Name
Mephenytoin   DM5UGDK
Synonyms
Epiazin; Epilan; Fenantoin; Insulton; Mefenetoin; Mefenitoina; Mephenetoinum; Mephentoin; Mephenytoine; Mephenytoinum; Mesantoin; Mesdontoin; Mesontoin; Methoin; Methylphenetoin; Metydan; Phenantoin; Phenylethylmethylhydantoin; Sacerno; Sedantional; Sedantoin; Sedantoinal; Triantoin; Ydantoin; Methyl Phenetoin; Methyl hydantoin; MU2276000; Gerot-epilan; L-Mephenytoin; Mefenitoina [INN-Spanish]; Mephenytoin [USAN:INN]; Mephenytoine [INN-French]; Mephenytoinum [INN-Latin]; Mesantoin (TN); Phenetoin, Methyl;Mephenytoin (USP/INN); L-3-Methyl-5-ethyl-5-phenylhydantoin; (+-)-5-Ethyl-3-methyl-5-phenylhydantoin; (+-)-Mephenytoin; (-)-5-Ethyl-3-methyl-5-phenylhydantoin; 3-Ethylnirvanol; 3-Methyl-5, 5-ethylphenylhydantoin; 3-Methyl-5,5-ethylphenylhydantoin; 3-Methyl-5,5-phenylethylhydantoin; 3-Methyl-5-ethyl-5-phenylh; 3-Methyl-5-ethyl-5-phenylhydantoin; 5 Ethyl 3 Methyl 5 Phenylhydantoin; 5-Ethyl-3-methyl-5-phenyl-2,4(3H,5H)-imidazoledione; 5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione; 5-Ethyl-3-methyl-5-phenylhydantoin; 5-Ethyl-3-methyl-5-phenylimidazolidin-2,4-dione; 5-Ethyl-5-fenyl-3-methylhydantoin; 5-Ethyl-5-fenyl-3-methylhydantoin [Czech]; 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
Indication
Disease Entry ICD 11 Status REF
Epilepsy 8A60-8A68 Approved [1]
Therapeutic Class
Anticonvulsants
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

57 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acetohexamide + Mephenytoin DCORZOH Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aciclovir + Mephenytoin DC5QWDY Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Mephenytoin DCRX3Q9 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Armodafinil + Mephenytoin DCMKAGT Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bepridil + Mephenytoin DCK6Y7F Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Mephenytoin DCYRHE1 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Mephenytoin DCKKHPF Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Mephenytoin DCPFXTS Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Mephenytoin DC6GBPM Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlormezanone + Mephenytoin DCGQGBW Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + Mephenytoin DCCN6NF Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Mephenytoin DCKPW73 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Darunavir + Mephenytoin DC9CVQ4 Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dexmedetomidine + Mephenytoin DCI2GH0 Dexmedetomidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Docetaxel + Mephenytoin DCGZ80E Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Endoxifen + Mephenytoin DCJHL9F Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + Mephenytoin DCHHUYH Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Mephenytoin DCSK32R IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lacosamide + Mephenytoin DC0E5SI Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Leflunomide + Mephenytoin DC95S7E Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Mephenytoin DCLKD8N Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Mebutamate DCWBU9R Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Dantrolene DCSMQ7F Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Diethylcarbamazine DCTYO5Z Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Citalopram DC1UNIU Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Terazosin DCO00KY Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Epinephrine DCE73XS Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Chlorphenesin DCBX9O3 Chlorphenesin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Vinblastine DC0QAY6 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Everolimus DCGE223 Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Testosterone cypionate DCMKV1G Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Bosentan DCYQQJH Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Tolvaptan DCOM1E7 Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Niclosamide DCVW2NI Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Diazoxide DC43P07 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Imatinib DCEAYW1 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Pramipexole DCRIPQX Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Valproic Acid DCHVNSH Valproic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Mycophenolic acid DCLFVVS Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Mefloquine DCHMWKN Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Pizotyline DCGVSG1 Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Doxorubicin DCGLCEB Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Silver sulfadiazine DC9ZELM Silver sulfadiazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Sumatriptan DCBJSDU Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methoxsalen + Mephenytoin DCIQJYD Methoxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Mephenytoin DCIK583 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Mephenytoin DCQPVBS Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pentamidine + Mephenytoin DCG0GYU Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PF-02545920 + Mephenytoin DC2WDTZ PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Probenecid + Mephenytoin DCB2DIQ Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Mephenytoin DC7TKKP Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ribavirin-TP + Mephenytoin DCVS160 Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
SCH 727965 + Mephenytoin DCMZXUV SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + Mephenytoin DCAO4MP Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trihexyphenidyl + Mephenytoin DCT0NJK Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + Mephenytoin DCWDLD0 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + Mephenytoin DCUNWAR Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 57 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7223).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.