Details of the Drug Combinations

General Information of This Drug (ID: DM625LN)

Drug Name

AG-041R DM625LN

Synonyms

AG-041R; LS-83786; 199800-49-2; GTPL901; MLS006010838; AG041R; CTK8E8139; DTXSID40430968; AG 041R; MolPort-009-019-290; ZINC3930890; NCGC00263225-01; SMR004701765; RT-011212; FT-0773348; J-012912

Indication

Disease Entry	ICD 11	Status	REF
Ulcerative colitis	DD71	Terminated	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AG-041R + Panobinostat	DC4OPI3	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
AG-041R + Ruxolitinib	DCF0ZCD	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 901).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.