Details of the Drug Combinations

General Information of This Drug (ID: DM6OLGC)

Drug Name
MK-3207   DM6OLGC
Synonyms
957116-20-0; MK-3207 Hydrochloride; MK-3207 (Hydrochloride); MK-3207 HCl; MK-3207 HCl salt; 2-((R)-8-(3,5-Difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-Pyrrolo[2,3-b]pyridin]-5-yl)acetamide hydrochloride; MK3207; (8R)-8-(3,5-Difluorophenyl)-10-oxo-n-[(2r)-1,1',2',3-tetrahydro-2'-oxospiro[2h-indene-2,3'-[3h]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride; MK 3207 hydrochloride; MK-3207(Hydrochloride); MK3207 HCl
Indication
Disease Entry ICD 11 Status REF
Migraine 8A80 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

19 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Artemisinin + MK-3207 DCPVYHZ Artemisinin Hepatoblastoma (Cell Line: HB3) [2]
Chloroquine + MK-3207 DCHZNV7 Chloroquine Hepatoblastoma (Cell Line: HB3) [2]
Lumefantrine + MK-3207 DCHVEA8 Lumefantrine DD2 (Cell Line: DD2) [2]
Lumefantrine + MK-3207 DCBGPIR Lumefantrine Hepatoblastoma (Cell Line: HB3) [2]
Mefloquine + MK-3207 DCLEOI3 Mefloquine Hepatoblastoma (Cell Line: HB3) [2]
MK-3207 + Lumefantrine DCPSRUR Lumefantrine DD2 (Cell Line: DD2) [2]
MK-3207 + Panobinostat DC54F2G Panobinostat DD2 (Cell Line: DD2) [2]
MK-3207 + Diltiazem DCZ8KAY Diltiazem DD2 (Cell Line: DD2) [2]
MK-3207 + Marizomib DCAXCO8 Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
MK-3207 + Idarubicin DCRKDX7 Idarubicin Glioblastoma? (Cell Line: T98G) [2]
MK-3207 + Artemisinin DCUTRV0 Artemisinin DD2 (Cell Line: DD2) [2]
MK-3207 + Piperaquine DCM13K5 Piperaquine DD2 (Cell Line: DD2) [2]
MK-3207 + Mefloquine DCO9CWU Mefloquine DD2 (Cell Line: DD2) [2]
MK-3207 + Lumefantrine DCLO2A1 Lumefantrine Hepatoblastoma (Cell Line: HB3) [3]
MK-3207 + Diltiazem DCD28DB Diltiazem Hepatoblastoma (Cell Line: HB3) [3]
MK-3207 + Elesclomol DCSCXOD Elesclomol Hepatoblastoma (Cell Line: HB3) [3]
MK-3207 + Chloroquine DCPYG6Z Chloroquine Hepatoblastoma (Cell Line: HB3) [3]
MK-3207 + Mefloquine DCSYGJS Mefloquine Hepatoblastoma (Cell Line: HB3) [3]
MK-3207 + Primaquine DC9PAZM Primaquine Hepatoblastoma (Cell Line: HB3) [3]
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⏷ Show the Full List of 19 DrugCom(s)

References

1 ClinicalTrials.gov (NCT00712725) MK3207 for Treatment of Acute Migraines (3207-005). U.S. National Institutes of Health.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.