General Information of This Drug (ID: DM7ISKJ)

Drug Name
Nisoldipine   DM7ISKJ
Synonyms
Baymycard; Nisocor; Nisoldipin; Nisoldipino; Nisoldipinum; Sular; Syscor; Zadipina; Bay k 5552; Nisoldipino [INN-Spanish]; Nisoldipinum [INN-Latin]; Sular (TN); Bay-k-5552; Nisoldipine (JAN/USAN/INN); Nisoldipine [USAN:BAN:INN:JAN]; Isobutyl 1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridincarboxylat;Methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (+-)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester; 3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [1]
Therapeutic Class
Antihypertensive Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Nisoldipine + Artemisinin DCDUCSZ Artemisinin DD2 (Cell Line: DD2) [2]
Nisoldipine + Chloroquine DCEX7F1 Chloroquine Hepatoblastoma (Cell Line: HB3) [2]
Nisoldipine + Piperaquine DCYTMGF Piperaquine DD2 (Cell Line: DD2) [2]
NITD609 + Nisoldipine DCL38ZQ NITD609 Hepatoblastoma (Cell Line: HB3) [3]
Proguanil + Nisoldipine DCTH8GH Proguanil DD2 (Cell Line: DD2) [2]
Proguanil + Nisoldipine DC30I48 Proguanil Hepatoblastoma (Cell Line: HB3) [2]
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⏷ Show the Full List of 6 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2524).
2 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
3 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976