Details of the Drug Combinations

General Information of This Drug (ID: DM7WFZ8)

Drug Name
FORMONONETIN   DM7WFZ8
Synonyms
formononetin; 485-72-3; Biochanin B; Formononetol; 7-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one; 7-Hydroxy-4'-methoxyisoflavone; 4'-O-methyldaidzein; 7-hydroxy-3-(4-methoxyphenyl)chromen-4-one; 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)-; UNII-295DQC67BJ; 7-Hydroxy-3-(4-methoxyphenyl)-4-benzopyrone; CHEBI:18088; Isoflavone, 7-hydroxy-4'-methoxy-; EINECS 207-623-9; NSC 93360; NSC-93360; 7-Hydroxy-3-(4-methoxyphenyl)chromone; 295DQC67BJ; HKQYGTCOTHHOMP-UHFFFAOYSA-N; NSC93360; AK106172
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

30 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + Formononetin DC1Q8UX (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + Formononetin DCBMCCC ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + Formononetin DCV35GB Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
Bardoxolone methyl + Formononetin DC4MDFI Bardoxolone methyl Hodgkin lymphoma (Cell Line: U-HO1) [2]
Cabozantinib + Formononetin DCQJZSY Cabozantinib Ewing sarcoma (Cell Line: TC-71) [2]
Cabozantinib + Formononetin DCX18PG Cabozantinib Hodgkin lymphoma (Cell Line: U-HO1) [3]
Carfilzomib + Formononetin DCKX137 Carfilzomib Ewing sarcoma (Cell Line: TC-71) [2]
CP-868596 + Formononetin DCJCNNN CP-868596 Ewing sarcoma (Cell Line: TC-71) [2]
Cycloheximide + Formononetin DC3AE64 Cycloheximide Ewing sarcoma (Cell Line: TC-71) [2]
Cycloheximide + Formononetin DC826GX Cycloheximide Hodgkin lymphoma (Cell Line: U-HO1) [3]
Everolimus + Formononetin DCKUQD2 Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Formononetin + Docetaxel DC152NI Docetaxel Ewing sarcoma (Cell Line: TC-71) [2]
Formononetin + THAPSIGARGIN DCCH2S6 THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
Formononetin + PHA-739358 DCG4THV PHA-739358 Ewing sarcoma (Cell Line: TC-71) [2]
Formononetin + Romidepsin DC24IBD Romidepsin Ewing sarcoma (Cell Line: TC-71) [2]
GDC-0084 + Formononetin DCG8AGK GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
Lestaurtinib + Formononetin DC556X0 Lestaurtinib Ewing sarcoma (Cell Line: TC-71) [2]
LY2874455 + Formononetin DC6NV5U LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
Mitomycin + Formononetin DCZG24A Mitomycin Ewing sarcoma (Cell Line: TC-71) [2]
Mitomycin + Formononetin DCTYVU7 Mitomycin Hodgkin lymphoma (Cell Line: U-HO1) [3]
MK-1775 + Formononetin DCZ0WBF MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
MK-2206 + Formononetin DCNZEIH MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
MK-2206 + Formononetin DC2JXK7 MK-2206 Hodgkin lymphoma (Cell Line: U-HO1) [2]
Nintedanib + Formononetin DC3TKUI Nintedanib Ewing sarcoma (Cell Line: TC-71) [2]
Nintedanib + Formononetin DC5UYL6 Nintedanib Hodgkin lymphoma (Cell Line: U-HO1) [3]
NVP-AUY922 + Formononetin DCQN7JA NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [2]
OSI-906 + Formononetin DCUV4MY OSI-906 Ewing sarcoma (Cell Line: TC-71) [3]
Panobinostat + Formononetin DCEGA57 Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
PD-0325901 + Formononetin DCJ4X5T PD-0325901 Hodgkin lymphoma (Cell Line: U-HO1) [3]
Romidepsin + Formononetin DC5WKTT Romidepsin Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 30 DrugCom(s)

References

1 Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.