General Information of This Drug (ID: DM8IC5H)

Drug Name
TRICIRIBINE   DM8IC5H
Synonyms
NSC154020; Akt Inhibitor V, Triciribine; MLS002702033; Akt/PKB Signaling Inhibitor-2; NSC-154020; TCN; Akt inhibitor V; AC1Q7CGY; AC1L6DVE; tricyclic nucleoside (TCN); SCHEMBL61269; GTPL5920; CHEMBL1892348; CHEBI:91697; HMS3268N05; HMS3654C06; HMS3229A09; HSCI1_000386; CCG-206732; 5-methyl-1-pentofuranosyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine; SMR001565606; SC-89664; NCI60_001091; Akt/protein kinase B signaling inhibitor-2; BRD-A42649439-001-01-0; BRD-A42649439-001-02-8; 1,5,6,8-Pentaazaacennaphthylen-3-amine, 1,5-dih
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

10 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Triciribine + Ruxolitinib DCZFYT3 Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
Triciribine + Trametinib DC3EVQJ Trametinib Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
Triciribine + Trametinib DC40TFR Trametinib Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
Triciribine + Trametinib DCCVL5E Trametinib Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
Triciribine + Panobinostat DC19WDK Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Triciribine + Marizomib DC0NGMU Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Triciribine + Cotellic DC3DVEO Cotellic Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
Triciribine + Cotellic DCPHXGK Cotellic Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
Triciribine + Cotellic DCIF4IT Cotellic Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
Triciribine + Idarubicin DC5GMQ0 Idarubicin Glioblastoma? (Cell Line: T98G) [2]
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⏷ Show the Full List of 10 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5920).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.