Details of the Drug Combinations

General Information of This Drug (ID: DM8QM5U)

Drug Name

Anidulafungin DM8QM5U

Synonyms

Ecalta; Eraxis; Anidulafungin [USAN:INN]; Ecalta (TN); Eraxis (TN); LY-303366; V-Echinocandin; VER-002

Indication

Disease Entry	ICD 11	Status	REF
Aspergillosis	1F20	Approved	[1]
Candidiasis	1F23	Approved	[2]
Convulsion	8A68.Z	Approved	[3]
Mycosis fungoides	2B01	Approved	[1]
Neuroaspergillosis	N.A.	Approved	[1]
Candidemia	1F23.3Y	Investigative	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[4]
Esophageal candidiasis	N.A.	Investigative	[1]
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Therapeutic Class

Antifungal Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Anidulafungin + Fluconazole	DCPOWF5	Fluconazole	Candidemia	[5]
Anidulafungin + Voriconazole	DCY6XBV	Voriconazole	Aspergillosis	[6]
Anidulafungin + Voriconazole	DC8PJGI	Voriconazole	Fungal infection	[7]
Anidulafungin + Voriconazole	DCCNNIS	Voriconazole	Invasive Candidiasis	[8]
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References

1	Anidulafungin FDA Label
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	Echinocandins: pharmacokinetic and therapeutic issues. Curr Med Res Opin. 2009 Jul;25(7):1741-50.
4	Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with higher interaction energy than Remdesivir, indicating potential in the treatment of Covid-19 infection. April.21.2020. Doi: 10.31219/osf.io/urxwh
5	ClinicalTrials.gov (NCT00761267) Study To Assess Pharmacokinetics, Safety & Efficacy of Anidulafungin When Treating Children With Invasive Candidiasis
6	ClinicalTrials.gov (NCT00531479) Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis
7	Clinical pipeline report, company report or official report of Pfizer.
8	ClinicalTrials.gov (NCT00689338) Anidulafungin Candidemia/Invasive Candidiasis Intensive Care Study