Details of the Drug Combinations

General Information of This Drug (ID: DM8WAHT)

• Drug Name: Fentanyl (DM8WAHT)
• Synonyms: fentanyl; Fentanil; Phentanyl; Fentora; Sublimaze; Fentanila; Fentanest; Duragesic; Fentanylum; Durogesic; Sentonil; 437-38-7; Duragesic-100; IONSYS; Duragesic-25; Duragesic-75; Duragesic-50; Duragesic-12; Fentanyl-25; Fentanyl-75; Fentanyl-12; Fentanyl-50; Fentanylum [INN-Latin]; Fentanila [INN-Spanish]; Fentanyl-100; 1-Phenethyl-4-N-propionylanilinopiperidine; Matrifen; Sublimase; N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide; N-(1-Phenethyl-4-piperidyl)propionanilide; N-Phenethyl-4-(N-propionylanilino)piperidine; Fentanil [DCIT]; Subsys; Fentanyl-37; Fentanyl-62; Fentanyl-87; Abstral; Actiq; Lazanda; Onsolis; Fentanyl Citrate; Fentanyl Citrate Preservative Free; Sublimaze Preservative Free; fentanyl (transmucosal film, pain), Auxilium Pharmaceuticals

Indication

Analgesia; ICD 11: MB40.8; Status: Approved [1]; Traumatic brain injury; ICD 11: NA07.Z; Status: Approved [2]; Cancer related pain; ICD 11: MG30; Status: Phase 3 [3]; Pain; ICD 11: MG30-MG3Z; Status: Phase 3 [4]; Chronic pain; ICD 11: MG30; Status: Phase 1 [5]

• Therapeutic Class: Neurology Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

58 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Esmolol + Fentanyl	DCOE8M2	Esmolol	Laparoscopic Surgery	[6]
Fentanyl + Propofol	DC4CHW4	Propofol	Obesity, Morbid	[7]
Fentanyl + Aspirin	DCBOMDD	Aspirin	Postoperative Pain	[8]
Fentanyl + Oxycodone	DCF2YHO	Oxycodone	Pain, Postoperative	[9]
Fentanyl + Morphine	DCGWXIN	Morphine	Hip Fractures	[10]
Fentanyl + Propofol	DCUJDNK	Propofol	Ventricular Tachycardia	[11]
Fentanyl + Propofol	DC6Q8SQ	Propofol	Hip Fractures	[12]
Fentanyl + Propofol	DCA9P4G	Propofol	Urinary Bladder Neoplasms	[13]
Fentanyl + Midazolam	DCAERTR	Midazolam	Prostatic Cancer	[14]
Fentanyl + Propofol	DCKIRKQ	Propofol	Renal Failure	[15]
Fentanyl + Ropivacaine	DCQ804I	Ropivacaine	Horner's Syndrome	[16]
Fentanyl + Ropivacaine	DCCIZZ4	Ropivacaine	Congenital Skelectal Anomaly	[17]
Fentanyl + Morphine	DCDK1G7	Morphine	Anesthesia	[18]
Fentanyl + Propofol	DCIATZ5	Propofol	Cirrhosis	[19]
Fentanyl + Naltrexone	DCID1BL	Naltrexone	Pain, Postoperative	[20]
Fentanyl + Midazolam	DCJ3323	Midazolam	Chronic Otitis Media	[21]
Fentanyl + Propofol	DCKD511	Propofol	Traumatic Brain Injury	[22]
Fentanyl + Remifentanil	DCMME74	Remifentanil	Postoperative Pain	[23]
Fentanyl + Midazolam	DCMU52D	Midazolam	Cirrhosis	[19]
Fentanyl + Labetalol	DCNO8W3	Labetalol	Laparoscopic Surgery	[6]
Fentanyl + Isoflurane	DCOJJC8	Isoflurane	Anesthesia; Adverse Effect	[24]
Fentanyl + Remimazolam	DCPWP9J	Remimazolam	Gastrointestinal Endoscopy	[25]
Fentanyl + Etomidate	DCS7FMK	Etomidate	Complication of Gastrostomy	[26]
Fentanyl + Oxycodone	DCU1U36	Oxycodone	Coughing Responses at Tracheal Extubation	[27]
Fentanyl + Lidocaine	DCU67I2	Lidocaine	Transient Neurologic Syndrome	[28]
Fentanyl + Acetaminophen	DCFARER	Acetaminophen	Emergence Agitation	[29]
Ketamine + Fentanyl	DCFJOV0	Ketamine	Procedural Sedation and Analgesia	[30]
Fentanyl + Remimazolam	DCGT2EP	Remimazolam	General Anesthesia	[31]
Levobupivacaine + Fentanyl	DCR3QSU	Levobupivacaine	Anesthesia	[32]
Fentanyl + Remimazolam	DC4G38Y	Remimazolam	General Anaesthesia	[33]
Fentanyl + Hydromorphone	DCHINVQ	Hydromorphone	Cancer	[34]
Fentanyl + Propofol	DCSB3HE	Propofol	Breast Cancer	[35]
Fentanyl + Propofol	DCZXTLI	Propofol	General Anaesthesia	[33]
Fentanyl + Morphine	DC1UNX9	Morphine	Obesity	[36]
Fentanyl + Ropivacaine	DC9UP3E	Ropivacaine	Breakthrough Pain	[37]
Fentanyl + Morphine	DCHIEYF	Morphine	Shoulder	[38]
Fentanyl + Hydromorphone	DCK1DM0	Hydromorphone	Opioid Use	[39]
Fentanyl + Midazolam	DC11XZ3	Midazolam	Mechanical Ventilation	[40]
Fentanyl + Propofol	DC5M9CK	Propofol	C.Surgical Procedure; Cardiac	[41]
Fentanyl + Ropivacaine	DCA86WI	Ropivacaine	Upper Extremity	[42]
Fentanyl + Acetaminophen	DCAB76M	Acetaminophen	Oocyte Retrieval	[43]
Fentanyl + Propofol	DCBE5BH	Propofol	Intubation, Intratracheal	[44]
Fentanyl + Propofol	DCBYVR4	Propofol	Mechanical Ventilation	[45]
Fentanyl + Propofol	DCCPQTH	Propofol	Opioid Use	[46]
Fentanyl + Lidocaine	DCFEH6M	Lidocaine	Coronary Artery Disease	[47]
Fentanyl + Flurbiprofen	DCNW9WI	Flurbiprofen	Sedation Complication	[48]
Fentanyl + Propofol	DCTXB3E	Propofol	Patient Satisfaction	[49]
Fentanyl + Flurbiprofen	DCW2UU8	Flurbiprofen	Sedation Complication	[48]
Fentanyl + Brilinta	DC31888	Brilinta	Percutaneous Coronary Intervention	[50]
Fentanyl + Remifentanil	DC7M5DK	Remifentanil	Chronic Pain	[51]
Fentanyl + Meperidine	DCFYN7L	Meperidine	Pain	[52]
Fentanyl + Chloroprocaine	DCMOUMQ	Chloroprocaine	Adverse Reaction to Spinal Anesthetic	[53]
Fentanyl + Ketorolac	DCRY4MD	Ketorolac	Pain, Postoperative	[54]
Ibuprofen + Fentanyl	DC3YPH0	Ibuprofen	Congenital Muscular Torticollis	[55]
Ketamine + Fentanyl	DCSVZZV	Ketamine	Ketamine	[56]
Ketamine + Fentanyl	DCVAZPS	Ketamine	Prostatic Cancer	[57]
Ketamine + Fentanyl	DCW1QAK	Ketamine	Postoperative Pain	[58]
Levobupivacaine + Fentanyl	DCKWQO1	Levobupivacaine	Epidural Analgesia	[59]

1 Approved Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Droperidol + Fentanyl	DC04SXC	Droperidol	Anaesthesia	[1]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Fentanyl FDA Label
• [3] ClinicalTrials.gov (NCT00822614) Safety of Fentanyl TAIFUN Treatment. U.S. National Institutes of Health.
• [4] A Phase III study to assess the clinical utility of low-dose fentanyl transdermal system in patients with chronic nonmalignant pain. Curr Med Res Opin. 2006 Aug;22(8):1493-501.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] ClinicalTrials.gov (NCT01114971) Labetalol and Esmolol: Vital Signs and Post Operative Pain Management
• [7] ClinicalTrials.gov (NCT03009877) Preoxygenation With Optiflow?in Morbidly Obese Patients is Superior to Face Mask
• [8] ClinicalTrials.gov (NCT03128346) Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery
• [9] ClinicalTrials.gov (NCT03529201) QLB After Nephrectomy
• [10] ClinicalTrials.gov (NCT03596060) Regional vs General Anesthesia in Patients With Hip Fracture Under Treatment With Clopidogrel
• [11] ClinicalTrials.gov (NCT02419547) Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia
• [12] ClinicalTrials.gov (NCT02604459) Does Optimized General Anesthesia Care Reduce Postoperative Delirium?
• [13] ClinicalTrials.gov (NCT02534623) Postoperative Quality of Recovery After Transurethral Resection of the Bladder
• [14] ClinicalTrials.gov (NCT01998685) Prothrombotic Factors and Anaesthesia in Prostate Cancer
• [15] ClinicalTrials.gov (NCT02037802) Caudal Epidural Catheterization in Pediatric Renal Transplant: Effect on Hemodynamics and Pain After Surgery
• [16] ClinicalTrials.gov (NCT02130739) Horner's SD After Thoracic Epidural Block
• [17] ClinicalTrials.gov (NCT02375191) A Comparative Study of the Effect of Epidural Dexmedetomidine Versus Fentanyl Added to Ropivacaine in Pediatric Orthopedic Surgery
• [18] ClinicalTrials.gov (NCT05533229) Fentanyl Versus Morphine in Spinal Anesthesia for Caesarian Section - Study on Analgesia, Side Effects and Patient 's Satisfaction
• [19] ClinicalTrials.gov (NCT00906139) Propofol and Fentanyl Versus Midazolam and Fentanyl for Endoscopy Sedation in Cirrhotic Patients
• [20] ClinicalTrials.gov (NCT01750060) Pharmacokinetic Characterization of the Active, Separated System With PK Controller (Fentanyl Iontophoretic Transdermal System, 40 Mcg Fentanyl Per Activation).
• [21] ClinicalTrials.gov (NCT01188551) Dexmedetomidine Versus Fentanyl Following Pressure Equalization Tube Placement
• [22] ClinicalTrials.gov (NCT01007773) Safety of Dexmedetomidine in Severe Traumatic Brain Injury
• [23] ClinicalTrials.gov (NCT02619032) Remifentanil and Fentanyl in Dental Surgery (REFEDS)
• [24] ClinicalTrials.gov (NCT03882788) The Effect of Anesthesia on Neurodevelopmental Outcome (NDO)
• [25] ClinicalTrials.gov (NCT05485064) Moderate Sedation Combined With Acupuncture Anesthesia in Gastroscopy and Colonoscopy on Screening Research
• [26] ClinicalTrials.gov (NCT01729897) Etomidate Emulsion for Sedation in Patients Scheduled for Upper Gastrointestinal (GI) Endoscopy
• [27] ClinicalTrials.gov (NCT03204045) Comparison of the Effects of Oxycodone Versus Fentanyl on Airway Reflex to Tracheal Extubation and Postoperative Pain
• [28] ClinicalTrials.gov (NCT01794247) Intrathecal Magnesium for Same-day-surgery
• [29] ClinicalTrials.gov (NCT03062488) Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery
• [30] ClinicalTrials.gov (NCT01126957) Combined Ketamine/Propofol for Emergency Department Procedural Sedation
• [31] ClinicalTrials.gov (NCT01937767) Remimazolam Phase II Cardiac Anesthesia Study
• [32] ClinicalTrials.gov (NCT02430090) Comparison of Intratechal Levobupivacaine and Adding With Sufetanil and Fentanyl in Ceserean Section
• [33] ClinicalTrials.gov (NCT03669484) Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia
• [34] ClinicalTrials.gov (NCT02084355) Study of Opioid Rotation Versus Opioid Escalation in Patients With Moderate to Severe Cancer Pain
• [35] ClinicalTrials.gov (NCT00542542) Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery
• [36] ClinicalTrials.gov (NCT02880540) Dexmedetomidine to Treat Bariatric Surgery-associated Pain
• [37] ClinicalTrials.gov (NCT02278601) Comparison of Regimens MPIB, CIPCEA, PCEA
• [38] ClinicalTrials.gov (NCT00702416) Ultrasound Guidance for Interscalene Brachial Plexus Block
• [39] ClinicalTrials.gov (NCT03726268) Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)
• [40] ClinicalTrials.gov (NCT02528513) Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients
• [41] ClinicalTrials.gov (NCT02119806) Decreasing the Incidence of Delirium After Cardiac Surgery
• [42] ClinicalTrials.gov (NCT00724035) Ultrasound-Guided Axillary or Infraclavicular Nerve Block for Upper Limb Surgery
• [43] ClinicalTrials.gov (NCT03105518) Predictors of Postoperative Pain Following Oocyte Retrieval for Assisted Reproduction
• [44] ClinicalTrials.gov (NCT04872881) Comparison of Effectiveness of Different Airway Management Methods During Percutaneous Tracheostomy
• [45] ClinicalTrials.gov (NCT01059929) Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
• [46] ClinicalTrials.gov (NCT03732469) Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization
• [47] ClinicalTrials.gov (NCT02683707) The Platelet Aggregation After tiCagrelor Inhibition and FentanYl Trial (PACIFY)
• [48] ClinicalTrials.gov (NCT04602845) Remimazolam Tosilate Sedation and Midazolam Sedation in Dental Patients
• [49] ClinicalTrials.gov (NCT03803449) Patient Satisfaction and Safety With Propofol Based Sedation With or Without Fentanyl for Gastrointestinal Endoscopy
• [50] ClinicalTrials.gov (NCT03476369) Fentanyl and Crushed Ticagrelor in Percutaneous Coronary Intervention
• [51] ClinicalTrials.gov (NCT02031016) Remifentanil vs Fentanyl During Cardiac Surgery and Chronic Thoracic Pain
• [52] ClinicalTrials.gov (NCT02684942) Comparison of Meperidine and Fentanyl on Pain Scale and QOL in Brachytherapy
• [53] ClinicalTrials.gov (NCT02862912) Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)
• [54] ClinicalTrials.gov (NCT02653742) Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children
• [55] ClinicalTrials.gov (NCT02651311) Ultrasound Guided Intermediate Cervical Plexus Block for Congenital Muscular Torticollis
• [56] ClinicalTrials.gov (NCT03666494) Ketamine Co-induction for Patients With Major Depressive Disorder
• [57] ClinicalTrials.gov (NCT02909049) Clinical Trial to Examine Individual Pain Tolerance in the Use of Two Anesthetic Techniques to Perform Saturation Prostate Biopsy
• [58] ClinicalTrials.gov (NCT03052673) Ketamine for Pain Relief in Bariatric Surgery
• [59] ClinicalTrials.gov (NCT04397406) Dexmedetomidine or Fentanyl as Additives to Epidural Levobupivacaine in Painless Labor