Details of the Drug Combinations

General Information of This Drug (ID: DMAOJBX)

Drug Name

Tetrandrine DMAOJBX

Synonyms

Tetrandrine, Millenia Hope; Tetrandrine, West Virginia University; Tranex-18

Indication

Disease Entry	ICD 11	Status	REF
Sarcoma	2A60-2C35	Phase 1	[1]
Colorectal cancer	2B91.Z	Discontinued in Phase 3	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Chloroquine + Tetrandrine	DCB1Z2O	Chloroquine	DD2 (Cell Line: DD2)	[3]
NITD609 + Tetrandrine	DCJOF8G	NITD609	DD2 (Cell Line: DD2)	[3]
NITD609 + Tetrandrine	DCXT2OI	NITD609	Hepatoblastoma (Cell Line: HB3)	[4]
Piperaquine + Tetrandrine	DCP0YM1	Piperaquine	Hepatoblastoma (Cell Line: HB3)	[4]
Tetrandrine + Artemether	DCENTZJ	Artemether	Hepatoblastoma (Cell Line: HB3)	[3]
Tetrandrine + Mefloquine	DCVLSWH	Mefloquine	Hepatoblastoma (Cell Line: HB3)	[3]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022136)
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.