Details of the Drug Combinations

General Information of This Drug (ID: DMBS370)

Drug Name

Tofacitinib DMBS370

Synonyms

Tasocitinib; 477600-75-2; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; CP-690550; CP 690550; racemic-tofacitinib; 1259404-17-5; tofacitinibum; CP-690,550; UNII-87LA6FU830; 3-((3R,4R)-rel-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile; Tofacitinib (CP-690550,Tasocitinib); CHEMBL221959; CHEBI:71200; Xeljanz (TN)

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[2]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Tofacitinib + Idarubicin	DCJFT42	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
------------------------------------------------------------------------------------

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Atorvastatin + Tofacitinib	DCPFZ2X	Atorvastatin	Rheumatoid Arthritis	[4]
Methotrexate + Tofacitinib	DC5IQZT	Methotrexate	Rheumatoid Arthritis	[5]
Meglumine antimoniate + Tofacitinib	DCPY27I	Meglumine antimoniate	Cutaneous Leishmaniasis, American	[6]
Tofacitinib + Hydroxychloroquine	DC8XX7S	Hydroxychloroquine	Pneumonitis, Interstitial	[7]
Methotrexate + Tofacitinib	DCI20T9	Methotrexate	Rheumatoid Arthritis	[8]
Prednisone + Tofacitinib	DC7TPNO	Prednisone	Arthritis, Rheumatoid	[9]
------------------------------------------------------------------------------------


⏷ Show the Full List of 6 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5677).
2	ClinicalTrials.gov (NCT04332042) TOFAcitinib in SARS-CoV2 Pneumonia. U.S. National Institutes of Health.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	ClinicalTrials.gov (NCT01059864) Study Of The Effects Of Atorvastatin On Cholesterol Levels In Rheumatoid Arthritis Patients Taking CP-690,550
5	ClinicalTrials.gov (NCT01745055) Co-Administration Of Methotrexate And CP-690,550
6	ClinicalTrials.gov (NCT06011343) Tofacitinib Associated With Meglumine Antimoniate in Cutaneous Leishmaniasis
7	ClinicalTrials.gov (NCT04390061) TOFAcitinib Plus Hydroxycloroquine vs Hydroxycloroquine in Patients With COVID-19 Interstitial Pneumonia
8	ClinicalTrials.gov (NCT02831855) Methotrexate Withdrawal Study of Tofacitinib Modified Release Formulation in Subjects With Rheumatoid Arthritis
9	ClinicalTrials.gov (NCT04928066) The Efficacy and Safety of Tofacitinib (TF) With Iguratimod (IGU) on RA