Details of the Drug Combinations

General Information of This Drug (ID: DMC40SD)

Drug Name
Darexaban maleate   DMC40SD
Synonyms
Darexaban maleate; UNII-03RTP2436R; 365462-24-4; 03RTP2436R; YM150; Darexaban maleate (JAN); SCHEMBL5406349; CHEMBL1922345; D09817; N-[2-[[4-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzoyl]amino]-3-hydroxyphenyl]-4-methoxybenzamide (2Z)-2-Butenedioate
Indication
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Discontinued in Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Darexaban maleate + Aspirin DC5MGAN Aspirin Pharmacodynamic Interaction [2]
Darexaban maleate + Ketoconazole DCAYQZN Ketoconazole Pharmacokinetics of Darexaban and Metabolites [3]
Darexaban maleate + Aspirin DCFHP3E Aspirin Pharmacodynamic and Pharmacokinetic Interaction [4]
Darexaban maleate + Aspirin DCHH0VW Aspirin Pharmacodynamic Interaction [2]
Darexaban maleate + Naproxen DCJG9AU Naproxen Pharmacodynamic Interaction [5]
Rifampicin + Darexaban maleate DCFVQJW Rifampicin Pharmacokinetics of Darexaban and Metabolites [6]
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⏷ Show the Full List of 6 DrugCom(s)

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020726)
2 ClinicalTrials.gov (NCT01409616) To Evaluate Whether Acetyl Salicylic Acid (Aspirin), the Combination of Aspirin and Clopidogrel and Darexaban (YM150) Interact in Their Effects
3 ClinicalTrials.gov (NCT01405989) To Evaluate if Multiple Doses of Ketoconazole Change the Blood Concentration of YM150 (Darexaban)
4 ClinicalTrials.gov (NCT01424332) To Evaluate Whether Acetyl Salicylic Acid (Aspirin) and Darexaban (YM150) Interact in Their Effects
5 ClinicalTrials.gov (NCT01409603) To Evaluate Whether Naproxen and Darexaban (YM150) Interact in Their Effects
6 ClinicalTrials.gov (NCT01406002) To Evaluate if Multiple Doses of Rifampicin Change the Blood Concentration of YM150 (Darexaban)