Details of the Drug Combinations

General Information of This Drug (ID: DMC9O43)

Drug Name

Sevoflurane DMC9O43

Synonyms

Sevofluran; Sevoflurano; Sevofluranum; Sevofrane; Sevorane; Sojourn; Ultane; Fluoromethyl hexafluoroisopropyl ether; Bax 3084; F0691; MR6S4; MR_6S4; PC4681; Sevoflurano [INN-Spanish]; Sevofluranum [INN-Latin]; Ultane (TN); Sevoflurane (JAN/USAN/INN); Sevoflurane [USAN:INN:BAN:JAN]; Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether; Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; Fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[2]
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Therapeutic Class

Anesthetics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

16 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Clonidine + Sevoflurane	DCMP1JA	Clonidine	Surgery	[3]
Desflurane + Sevoflurane	DCTDREJ	Desflurane	Postoperative Delirium	[4]
Propofol + Sevoflurane	DCGMQ2Z	Propofol	Cardiac On-pump Surgery	[5]
Rocuronium + Sevoflurane	DCEHBEX	Rocuronium	Muscle Relaxation	[6]
Sufentanil + Sevoflurane	DC2OMFC	Sufentanil	Ischemic Heart Disease	[7]
Ketamine + Sevoflurane	DCBWKJW	Ketamine	Anesthesia	[8]
Lidocaine + Sevoflurane	DC3N734	Lidocaine	Colonic Cancer	[9]
Etomidate + Sevoflurane	DC6T6OA	Etomidate	Anesthesia	[10]
Isoflurane + Sevoflurane	DCZFAHD	Isoflurane	Delirium on Emergence	[11]
Ketamine + Sevoflurane	DCUGEB4	Ketamine	Depressive Disorder	[12]
Propofol + Sevoflurane	DCETHLE	Propofol	PONV	[13]
Propofol + Sevoflurane	DC9OP5V	Propofol	Delirium on Emergence	[11]
Rocuronium + Sevoflurane	DCLTE3D	Rocuronium	Muscle Relaxation Caused by Sevoflurane	[14]
Ropivacaine + Sevoflurane	DCMVRYR	Ropivacaine	Agitation	[15]
Sevoflurane + Remifentanil	DC88V2F	Remifentanil	Haemodynamic Rebound	[16]
Sevoflurane + Remifentanil	DCO1IZT	Remifentanil	Intra-abdominal and Intrapelvic Surgery	[17]
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⏷ Show the Full List of 16 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7296).
2	Sevoflurane in COVID-19 ARDS (SevCov)
3	ClinicalTrials.gov (NCT06287151) Regional Anesthesia EMG Study
4	ClinicalTrials.gov (NCT04707794) Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery
5	ClinicalTrials.gov (NCT00924222) Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass
6	ClinicalTrials.gov (NCT00984633) Study of Efficacy, Pharmacokinetics, and Safety of Bolus Maintenance Doses of Org 9426 (Study P05976)(COMPLETED)
7	ClinicalTrials.gov (NCT02499445) Myocardial Injury in Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimens in OPCAB Surgery
8	ClinicalTrials.gov (NCT03503578) EEG Studies of Sevoflurane-Induced General Anesthesia
9	ClinicalTrials.gov (NCT04316013) Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: The VAPOR-C Trial
10	ClinicalTrials.gov (NCT02500225) Comparison the Effects of Etomidate and Sevoflurane During Electroconvulsive Therapy
11	ClinicalTrials.gov (NCT02111447) Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI
12	ClinicalTrials.gov (NCT02267980) Effect of the Addition of Ketamine to Sevoflurane Anesthesia in Electroconvulsive Therapy
13	ClinicalTrials.gov (NCT02809378) The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV
14	ClinicalTrials.gov (NCT02785653) Effect of Sevoflurane on the Onset Characteristics and Intubating Conditions of Rocuronium
15	ClinicalTrials.gov (NCT02428283) Scalp Nerve Block on Emergence Agitation
16	ClinicalTrials.gov (NCT02271555) The Effects of Remifentanil on Attenuating the Hemodynamic Responses After Electroconvulsive Therapy
17	ClinicalTrials.gov (NCT01809041) Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction