Details of the Drug Combinations

General Information of This Drug (ID: DMCA7FN)

Drug Name

Exatecan DMCA7FN

Synonyms

Exatecan mesylate; DX-8951; DX-8951a; DX-8951f; UM-1; UM-2

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Exatecan + Panobinostat	DCYYLUQ	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Exatecan + Ruxolitinib	DCW090B	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
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References

1	ClinicalTrials.gov (NCT00023972) Gemcitabine With or Without Exatecan Mesylate in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer. U.S. National Institutes of Health.
2	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
3	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976