Details of the Drug Combinations

General Information of This Drug (ID: DMCD9YG)

• Drug Name: Prazosin (DMCD9YG)
• Synonyms: Furazosin; Justac; Lentopres; Prazocin; Prazosina; Prazosine; Prazosinum; Prazosin HCl; TNP00312; CP-12299; Hypovase (TN); Minipress (TN); Prazosin (INN); Prazosin [INN:BAN]; Prazosina [INN-Spanish]; Prazosine [INN-French]; Prazosinum [INN-Latin]; Vasoflex (TN); [3H]-Prazosin; [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone; [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone; [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone; Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-(9CI); Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-(8CI); 1-(3-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) piperazine; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine; 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline; 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine; 4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone

Indication

Benign prostatic hyperplasia; ICD 11: GA90; Status: Approved [1]; Congestive heart failure; ICD 11: BD10; Status: Approved [1]; Hypertension; ICD 11: BA00-BA04; Status: Approved [1]; Coronavirus Disease 2019 (COVID-19); ICD 11: 1D6Y; Status: Phase 2 [2]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

12 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AS602868 + Prazosin	DCQHEB2	AS602868	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
Daporinad + Prazosin	DCBHSYQ	Daporinad	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
Fostamatinib + Prazosin	DC9XT4O	Fostamatinib	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
IMD-0354 + Prazosin	DCD4RGR	IMD-0354	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
Mefloquine + Prazosin	DCFTUOE	Mefloquine	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
PD-0325901 + Prazosin	DCKWZGL	PD-0325901	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
Prazosin + CYTISINE	DCUCTJF	CYTISINE	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
Prochlorperazine + Prazosin	DCPGKYD	Prochlorperazine	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
RTB101 + Prazosin	DCCTQBV	RTB101	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
SNS-032 + Prazosin	DC2YO04	SNS-032	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
THAPSIGARGIN + Prazosin	DCL9I1D	THAPSIGARGIN	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
Trametinib + Prazosin	DC58PAT	Trametinib	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[4]

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Propranolol + Prazosin	DCPAPQW	Propranolol	Post-traumatic Stress Disorder (PTSD)	[5]
Varenicline + Prazosin	DCRH4DS	Varenicline	Cigarette Smoking	[6]
Cyproheptadine + Prazosin	DCA54P3	Cyproheptadine	Alcohol Use Disorder	[7]
Prazosin + Naltrexone	DCLRE8B	Naltrexone	Alcohol Use Disorder	[8]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Prazosin to Prevent COVID-19 (PREVENT-COVID Trial) (PREVENT)
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT05189977) A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline
• [6] ClinicalTrials.gov (NCT02193256) Varenicline + Prazosin for Heavy Drinking Smokers
• [7] ClinicalTrials.gov (NCT04108104) Clinical Outcome of a Patented Pharmaceutical Composition (KT-110) to Treat Alcohol Use Disorder While Avoiding Major Side Effects
• [8] ClinicalTrials.gov (NCT02322047) Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders