Details of the Drug Combinations

General Information of This Drug (ID: DMCL2OK)

• Drug Name: Disulfiram (DMCL2OK)
• Synonyms: Abstenisil; Abstinil; Abstinyl; Alcophobin; Antabus; Antabuse; Antadix; Antaenyl; Antaethan; Antaethyl; Antaetil; Antalcol; Antetan; Antethyl; Antetil; Anteyl; Anthethyl; Antiaethan; Anticol; Antietanol; Antiethanol; Antietil; Antikol; Antivitium; Aversan; Averzan; Bonibal; Contralin; Contrapot; Cronetal; Dicupral; Disetil; Disulfan; Disulfirame; Disulfiramo; Disulfiramum; Disulfirm; Disulfram; Disulfuram; Disulphuram; Ephorran; Espenal; Esperal; Etabus; Ethyldithiourame; Ethyldithiurame; Exhoran; Exhorran; Gababentin; Hoca; Krotenal; Nocbin; Nocceler; Noxal; Refusal; Stopaethyl; Stopethyl; Stopety; Stopetyl; TATD; TETD; THIOCID; TTD; TTS; Tenurid; Tenutex; Tetidis; Tetradin; Tetradine; Tetraethylthiuram; Tetraetil; Teturam; Teturamin; Thireranide; Thiuranide; Tillram; Tiuram; Accel TET; Akrochem TETD; Ancazide ET; Antab use; Disulfirame [DCIT]; Ekagom DTET; Ekagom TEDS; Ekagom TETDS; Ekaland TETD; Esperal [France]; Eta bus; Ethyl Thiram; Ethyl Thiudad; Ethyl Thiurad; Ethyl Tuads Rodform; Ethyl Tuex; Ethyl tuads; Etyl Tuex; Nocceler TET; Perkacit TETD; Perkait TETD; Robac TET; Sanceler TET; Soxinol TET; TTS x; Tet raethylthiuram; Thiuram E; Dupon 4472; T 1132; Accel TET-R; Alk-aubs; Antabus (TN); Antabuse (TN); Anti-ethyl; Antivitium (Spain); ENT 27,340; Nocceler TET-G; Noxal (VAN); Ro-sulfiram; Sanceler TET-G; Tuads, ethyl; Usaf B-33; Ro-Sulfram-500 (USA)

Indication

Alcohol dependence; ICD 11: 6C40.2; Status: Approved [1]; Coronavirus Disease 2019 (COVID-19); ICD 11: 1D6Y; Status: Investigative [2]; Middle East Respiratory Syndrome (MERS); ICD 11: 1D64; Status: Investigative [3]; Severe acute respiratory syndrome (SARS); ICD 11: 1D65; Status: Investigative [3]

• Therapeutic Class: Alcohol Deterrents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Disulfiram + Idarubicin	DCVGATN	Idarubicin	Glioblastoma? (Cell Line: T98G)	[4]

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Disulfiram + Naltrexone	DC0PPRT	Naltrexone	Alcohol-Related Disorders	[5]
Disulfiram + Methadone	DC9EREC	Methadone	Cocaine Dependence	[6]
Disulfiram + E-2007	DC31U6E	E-2007	Alcohol Disorders	[7]
Disulfiram + Temozolomide	DCSQU8T	Temozolomide	Glioblastoma	[8]
Disulfiram + Lomustine	DCLKDNQ	Lomustine	Glioma	[9]
Disulfiram + Osimertinib	DCOHFV6	Osimertinib	Non-Small Cell Lung Cancer	[10]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9.
• [3] Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150.
• [4] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [5] ClinicalTrials.gov (NCT00142844) Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1
• [6] ClinicalTrials.gov (NCT00149630) Pharmacogenetics of Disulfiram for Cocaine
• [7] ClinicalTrials.gov (NCT04502589) Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder
• [8] ClinicalTrials.gov (NCT01907165) Disulfiram in Treating Patients With Glioblastoma Multiforme After Radiation Therapy With Temozolomide
• [9] ClinicalTrials.gov (NCT02678975) Disulfiram in Recurrent Glioblastoma
• [10] ClinicalTrials.gov (NCT03944772) Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)