Details of the Drug Combinations

General Information of This Drug (ID: DMCV602)

Drug Name
LY2523355   DMCV602
Synonyms Litronesib
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

20 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + LY2523355 DCX9FPN (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + LY2523355 DCMUE0K ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
Everolimus + LY2523355 DCR41TG Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + LY2523355 DC55N04 Exherin Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + AZD8055 DC1WOPI AZD8055 Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + Everolimus DC5B00B Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + GDC-0084 DCSYZVT GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + SCH 727965 DCY5MEJ SCH 727965 Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + THAPSIGARGIN DCT6GQG THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + Etoposide DC0EYGM Etoposide Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + AEE-788 DC5HS0D AEE-788 Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + Pelitinib DC5VB5Y Pelitinib Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + ABT-263 DCRLRHD ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + Bardoxolone methyl DCH5XRP Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + Decitabine DCJ1EIO Decitabine Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + Cytarabine DCFSURR Cytarabine Ewing sarcoma (Cell Line: TC-71) [2]
LY2523355 + Ruxolitinib DCTN8DQ Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
OSI-027 + LY2523355 DCDOYAE OSI-027 Ewing sarcoma (Cell Line: TC-71) [2]
OSI-906 + LY2523355 DCWVOL1 OSI-906 Ewing sarcoma (Cell Line: TC-71) [3]
Panobinostat + LY2523355 DC9WZ80 Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
------------------------------------------------------------------------------------
⏷ Show the Full List of 20 DrugCom(s)

References

1 ClinicalTrials.gov (NCT01416389) A Study of LY2523355 in Patients With Breast Cancer. U.S. National Institutes of Health.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.