Details of the Drug Combinations

General Information of This Drug (ID: DMD157S)

Drug Name

Montelukast DMD157S

Synonyms

Brondilat; Montair; Singular; Apxi toxin; MK 0476; Brondilat (TN); MK-0476; Montelukast (INN); Montelukast [INN:BAN]; Singulair (TN); Sodium 1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropylacetate; {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid; (R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid; 1-((((1R)-1-(3-((1E)-2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid; 2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Allergic asthma	CA23.0	Approved	[1]
Allergic rhinitis	CA08.0	Approved	[1]
Asthma	CA23	Approved	[2]
Intrinsic asthma	N.A.	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2/3	[3]
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Therapeutic Class

Antiasthmatic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

10 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Beclomethasone dipropionate + Montelukast	DCRK9J1	Beclomethasone dipropionate	Asthma	[4]
Budesonide + Montelukast	DC3E7D3	Budesonide	Obstructive Sleep Apnea Syndrome	[5]
Budesonide + Montelukast	DCMZHJ2	Budesonide	Asthma	[6]
Ivermectin + Montelukast	DC2PVOE	Ivermectin	Covid19	[7]
Loratadine + Montelukast	DCKO6BT	Loratadine	Allergic rhinitis	[8]
Mometasone + Montelukast	DCR518D	Mometasone	Asthma	[9]
Montelukast + Hydroxychloroquine	DCTRRRI	Hydroxychloroquine	Covid19	[7]
Fexofenadine + Montelukast	DCAVKH4	Fexofenadine	Allergic Rhinitis	[10]
Montelukast + Levocetirizine	DCG8FA3	Levocetirizine	Allergic Rhinitis	[10]
Montelukast + FP-187	DCJKXOF	FP-187	Multiple Sclerosis	[11]
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⏷ Show the Full List of 10 DrugCom(s)

References

1	Montelukast FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3340).
3	The COvid-19 Symptom MOntelukast Trial (COSMO)
4	ClinicalTrials.gov (NCT00911547) The Clinical Effect of MK0476 With Concomitant Administration of and Removal of Inhaled Beclomethasone in Asthmatic Patients (0476-029)
5	ClinicalTrials.gov (NCT00912171) Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children
6	ClinicalTrials.gov (NCT00462592) Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
7	ClinicalTrials.gov (NCT04714515) Montelukast - a Treatment Choice for COVID-19
8	Montelukast, a leukotriene receptor antagonist, for the treatment of persistent asthma in children aged 2 to 5 years. Pediatrics. 2001 Sep;108(3):E48.
9	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029434)
10	ClinicalTrials.gov (NCT02551536) Montelukast and Fexofenadine Versus Montelukast and Levocetrizine Combination in Allergic Rhinitis
11	ClinicalTrials.gov (NCT02410278) Study of Montelukast on Gastrointestinal Tolerability in Patients With Relapsing Forms of Multiple Sclerosis Receiving Tecfidera