Details of the Drug Combinations

General Information of This Drug (ID: DMD9WSC)

Drug Name
Memantine   DMD9WSC
Synonyms Memantine ER; Namenda XR; Memantine (extended release); Memantine (extended release), Forest
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Approved [1]
Asperger syndrome N.A. Approved [2]
Glioblastoma 2A00 Approved [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

72 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abacavir + Memantine DC2N13Y Abacavir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acarbose + Memantine DCJP2YQ Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Allopurinol + Memantine DCNIKHW Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Anamorelin + Memantine DCICLPQ Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Arfolitixorin + Memantine DCGAN6Z Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Asenapine + Memantine DCPE3AA Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Memantine DCG0YE4 Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Memantine DC4N7LT Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Busulfan + Memantine DCICI5R Busulfan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Memantine DCGD0A6 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chloroquine + Memantine DCGQN8M Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorzoxazone + Memantine DC26JX2 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Citalopram + Memantine DCT32ZB Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Clascoterone + Memantine DCMQ4K7 Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cytarabine + Memantine DCM5R9K Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Desoxycorticosterone pivalate + Memantine DCGTI8H Desoxycorticosterone pivalate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Docetaxel + Memantine DCAT0IY Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Emetine + Memantine DC7B67E Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Entacapone + Memantine DCZRNKN Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Epinephrine + Memantine DC27FXI Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Everolimus + Memantine DCWKD22 Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Gefitinib + Memantine DCD7TCO Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Memantine DC1NCVS Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Itraconazole + Memantine DC5JWUU Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
K-134 + Memantine DC9V59H K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Meclofenamic acid DCSBEUQ Meclofenamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Lefaxin DCRJNM5 Lefaxin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Pentostatin DCHG4KT Pentostatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Dantrolene DCEQS9F Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Vinblastine DC5W2KF Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Testosterone DCXSWUT Testosterone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + IT-141 DCZBCVU IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Efavirenz DCSFPPV Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Ursodeoxycholic acid DC78Y5P Ursodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Carglumic acid DCCB4IK Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Metformin DCHARJ0 Metformin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + JZL195 DCMZC4F JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Ginsenoside Rb1 DCXMPGX Ginsenoside Rb1 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Armodafinil DCZWFT6 Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Zaleplon DCNYD6T Zaleplon Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Triflupromazine DCCJQIE Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + BIO-300 DC94JBQ BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Eflornithine DCQ85OV Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Fenoprofen DCX7UMG Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Tamoxifen DCC58O8 Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Pargyline DCFTZWI Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + BRL-15572 DCIUQZE BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Probenecid DCYONPQ Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Atenolol DCJSWYT Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Linagliptin DCJU074 Linagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Acetohexamide DCN3FZT Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Endoxifen DCUCI3O Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Mycophenolic acid DC32IWC Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Olmesartan medoxomil DC8DFPB Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Auranofin DCTBN7D Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Estramustine DCS8JHB Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Cerivastatin DCRY54V Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Metaxalone DCUU30O Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Memantine + Azatadine DCFWW10 Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methotrexate + Memantine DCG75B3 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Metyrosine + Memantine DCIY2II Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Picoplatin + Memantine DCR8WJ5 Picoplatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pinacidil + Memantine DCWOYA3 Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PMID28460551-Compound-2 + Memantine DCU7KQ4 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pramipexole + Memantine DC2Q96L Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sulfapyridine + Memantine DC1EP6T Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sumatriptan + Memantine DC60J3Q Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Testosterone cypionate + Memantine DC9HIUK Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tindamax + Memantine DC069T7 Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triapine + Memantine DC809R2 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trimethobenzamide + Memantine DC4FMZN Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tropisetron + Memantine DCLYJ6G Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 72 DrugCom(s)
4 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Memantine + Naltrexone DC3NFUF Naltrexone Opioid Dependence [5]
Memantine + Riluzole DCF92GK Riluzole Mood [6]
Memantine + Riluzole DCN01SS Riluzole Amyotrophic Lateral Sclerosis [7]
Memantine + Escitalopram DC7E1VA Escitalopram Mild Cognitive Impairment [8]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4253).
2 Memantine FDA Label
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5 ClinicalTrials.gov (NCT00125515) Memantine and Naltrexone Treatment for Opioid Dependence
6 ClinicalTrials.gov (NCT00283309) Memantine or Riluzole Prophylaxis for Corticosteroid-induced Mood and Declarative Memory Changes
7 ClinicalTrials.gov (NCT00353665) Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS)
8 ClinicalTrials.gov (NCT01876823) Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment