Details of the Drug Combinations

General Information of This Drug (ID: DMDL27I)

Drug Name

Oxytocin DMDL27I

Synonyms

OXYTOCIN; Pitocin; 50-56-6; Ocytocin; Endopituitrina; Orasthin; Syntocinon; Oxytocine; Oxitocina; Oxytocinum; (1-Hemicystine)oxytocin; Piton S; Oxytocic hormone; UNII-1JQS135EYN; 3-Isoleucine-8-leucine vasopressin; Partocon; Oxystin; alpha-Hypophamine; Synthetic oxytocin; 1JQS135EYN; Ocytocinum; Syntocinone; Utedrin; Oxtocin; Uteracon; Syntocin; Synpitan; Presoxin; Di-sipidin; CHEMBL395429; CHEBI:7872; Nobitocin S; Atonin O; Oxetakain [Czech]; Ossitocina [DCIT]; Oxytocine [INN-French]; Oxytocinum [INN-Latin]; Oxitocina [INN-Spanish]; Posterior; Oxytocin (intranasal/ muco system, autism); [3H]OT (human, mouse, rat)

Indication

Disease Entry	ICD 11	Status	REF
Autism spectrum disorder	6A02	Approved	[1]
Ductal breast carcinoma in situ	N.A.	Approved	[2]
Postpartum haemorrhage	JA43	Approved	[2]
Lactation failure	JB46.3	Phase 3	[3]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[4]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

16 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ergonovine + Oxytocin	DCXKHL5	Ergonovine	Postpartum Hemorrhage	[5]
Ergonovine + Oxytocin	DC8MZXF	Ergonovine	Cesarean Section Complications	[6]
Misoprostol + Oxytocin	DCLS851	Misoprostol	Vaginal Delivery	[7]
Oxytocin + Oxytocin	DC2D81A	Oxytocin	Postpartum Hemorrhage	[5]
Oxytocin + Carboprost tromethamine	DC30LCB	Carboprost tromethamine	Postpartum Hemorrhage	[5]
Oxytocin + Carbetocin	DCSPUVW	Carbetocin	Postpartum Hemorrhage	[5]
Oxytocin + Carbetocin	DC0F4ZF	Carbetocin	Postpartum Hemorrhage	[8]
Oxytocin + Carboprost tromethamine	DC3O1YE	Carboprost tromethamine	Postpartum Hemorrhage	[9]
Oxytocin + Magnesium Sulfate	DCB1LU4	Magnesium Sulfate	Postpartum Hemorrhage	[10]
Oxytocin + Phenylephrine	DCBP3YY	Phenylephrine	Postpartum Hemorrhage	[11]
Oxytocin + Norepinephrine	DCN6TM6	Norepinephrine	Postpartum Hemorrhage	[11]
Oxytocin + Etomidate	DCULI8G	Etomidate	Postpartum Hemorrhage	[12]
Oxytocin + Propofol	DCYF1PZ	Propofol	Postpartum Hemorrhage	[12]
Propranolol + Oxytocin	DCH6BK8	Propranolol	Postpartum Hemorrhage	[13]
Propranolol + Oxytocin	DCRWUJM	Propranolol	Poor; Labor	[14]
Oxytocin + Carbetocin	DC0ABT2	Carbetocin	CARBETOCIN FOR PREVENTION OF PLACENTAL RETAINED	[15]
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⏷ Show the Full List of 16 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2174).
2	Oxytocin FDA Label
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039450)
4	Phase II RCT to Assess Efficacy of Intravenous Administration of Oxytocin in Patients Affected by COVID-19 (OsCOVID19)
5	ClinicalTrials.gov (NCT06285409) Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium
6	ClinicalTrials.gov (NCT03578263) Carbetocin Versus Oxytocin and Ergometrine for the Prevention of Postpartum Hemorrhage
7	ClinicalTrials.gov (NCT04004845) Labor Protocol Study
8	ClinicalTrials.gov (NCT01689298) Carbetocin vs. Oxytocin: In-vitro Myometrial Contractions With and Without Oxytocin Pre-treatment
9	ClinicalTrials.gov (NCT01869556) Comparison of IV Ergonovine With IM Carboprost, With Oxytocin IV, During Cesarean Section for Failure to Progress
10	ClinicalTrials.gov (NCT02647268) Effect of Magnesium Sulphate Pre-exposure on Oxytocin-induced Contractility in Desensitized Human Myometrium - an in Vitro Study
11	ClinicalTrials.gov (NCT06285396) Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
12	ClinicalTrials.gov (NCT03852797) Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium
13	ClinicalTrials.gov (NCT03434444) In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol
14	ClinicalTrials.gov (NCT02702674) The Effect of Coadministration of Oral Propranolol to Oxytocin on Induction of Labor
15	ClinicalTrials.gov (NCT01827124) Randomized Clinical Trial for Comparison Of Intravenous Carbeitocin Versus Oxytocin In Management Of Placental Delivery In Second Trimester Interruption