General Information of This Drug (ID: DMEFRTZ)

Drug Name
Lurbinectedin   DMEFRTZ
Synonyms UNII-2CN60TN6ZS; 497871-47-3; 2CN60TN6ZS; Lurbinectedin [INN]; SCHEMBL16152477; DTXSID30198065; DB12674; CS-6323; HY-16293; J3.652.626B
Indication
Disease Entry ICD 11 Status REF
Small-cell lung cancer 2C25.Y Approved [1]
leukaemia 2A60-2B33 Phase 3 [2]
Ovarian cancer 2C73 Phase 3 [2]
Endometrial cancer 2C76 Phase 2 [3]
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Lurbinectedin + Irinotecan DCGY15S Irinotecan Advanced Solid Tumors [4]
Lurbinectedin + Bosentan DCSVAAX Bosentan Advanced Solid Tumor [5]
Lurbinectedin + Capecitabine DCX4FUD Capecitabine Metastatic Breast Cancer [6]
Gemcitabine + Lurbinectedin DCPZVML Gemcitabine Non-Small Cell Lung Cancer (NSCLC) [7]
Lurbinectedin + Doxorubicin DCW7PJ4 Doxorubicin Metastatic Sarcoma [8]
Amrubicin + Lurbinectedin DC37XA4 Amrubicin Small Cell Lung Cancer [9]
Amrubicin + Lurbinectedin DC8P6ID Amrubicin Small Cell Lung Cancer (SCLC) [10]
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⏷ Show the Full List of 7 DrugCom(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
2 ClinicalTrials.gov (NCT02421588) Clinical Trial of Lurbinectedin (PM01183) in Platinum Resistant Ovarian Cancer Patients. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 ClinicalTrials.gov (NCT02611024) Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors
5 ClinicalTrials.gov (NCT05072106) Study to Evaluate the Effect of Bosentan on the Pharmacokinetics of Lurbinectedin in Patients With Advanced Solid Tumors
6 ClinicalTrials.gov (NCT02210364) Study of Lurbinectedin (PM01183) in Combination With Capecitabine in Patients With Metastatic Breast Cancer (MBC), Pancreatic Cancer (PC) or Metastatic Colorectal Cancer (CRC).
7 ClinicalTrials.gov (NCT01951157) A Clinical Study in Three-arm of Lurbinectedin (PM01183) Alone or in Combination With Gemcitabine and a Control Arm With Docetaxel as Second Line Treatment in Non-Small Cell Lung Cancer (NSCLC) Patients
8 ClinicalTrials.gov (NCT02448537) A Phase II Multi-Strata Study of PM01183 as a Single Agent or in Combination With Conventional Chemotherapy in Metastatic and/or Unresectable Sarcomas
9 ClinicalTrials.gov (NCT06203210) A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
10 ClinicalTrials.gov (NCT05740566) Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer