Details of the Drug Combinations

General Information of This Drug (ID: DMEO794)

• Drug Name: Galantamine (DMEO794)
• Synonyms: GNT; Galantamin; Galantamina; Galantaminum; Galanthamine; Galanthaminum; Jilkon; Lycoremin; Lycoremine; Reminyl; Razadyne ER; Galantamina [INN-Spanish]; Galantamine [USAN:INN]; Galantaminum [INN-Latin]; Nivalin (TN); Razadyne (TN); Razadyne ER (TN); Reminyl (TN); Galantamine (USAN/INN); (-)-Galanthamine; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro(3a,3,2-ef)(2)benzazepin-6-ol

Indication

Alzheimer disease; ICD 11: 8A20; Status: Approved [1]; Traumatic brain injury; ICD 11: NA07.Z; Status: Approved [2]

• Therapeutic Class: Parasympathomimetics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

61 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Galantamine	DC9JARX	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Anamorelin + Galantamine	DCDXJ5I	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Artemisinin + Galantamine	DC4REB4	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bepridil + Galantamine	DC5BTZS	Bepridil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Galantamine	DCZFODJ	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Galantamine	DCHUU8T	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Galantamine	DCBL5L1	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cevimeline + Galantamine	DC3DUCK	Cevimeline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilostazol + Galantamine	DCIM97Q	Cilostazol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dantrolene + Galantamine	DCX6MRW	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Desoxycorticosterone pivalate + Galantamine	DCPK12O	Desoxycorticosterone pivalate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diazoxide + Galantamine	DCAB55T	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diethylcarbamazine + Galantamine	DC5OCF4	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Efavirenz + Galantamine	DCONP5F	Efavirenz	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Emetine + Galantamine	DC4USTP	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Galantamine	DCW70AY	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fosfomycin + Galantamine	DC5B0RS	Fosfomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Aprepitant	DCCHHGD	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Kanamycin	DCVQF0K	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Epinephrine	DCYLUAQ	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Sivelestat	DCS8ROF	Sivelestat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Terameprocol	DC91LMR	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Chlorzoxazone	DCB7RIN	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + JZL195	DCSNNLQ	JZL195	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Isoproterenol	DC60L7C	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Fenoprofen	DCC3X4H	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Darunavir	DCVVZ7Q	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Methylene blue	DCQ2BSS	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Oxyphenbutazone	DCAT3AN	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Brincidofovir	DCD8A1O	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Sorafenib	DCDM0XQ	Sorafenib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Quinine	DCHY3WV	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Lacosamide	DCN8XP2	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Auranofin	DCYNZCX	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Vorinostat	DCR9UOH	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Cerivastatin	DC97P2J	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Busulfan	DCMIZ7D	Busulfan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + ML323	DC3YF55	ML323	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Tacrolimus	DCYTN91	Tacrolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Tetracycline	DCXENFQ	Tetracycline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Cytarabine	DCSGHDX	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Gefitinib + Galantamine	DC7N167	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Hyodeoxycholic acid + Galantamine	DCFEKK5	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Idarubicin + Galantamine	DCLUJ1I	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
IT-141 + Galantamine	DCNNN5K	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Galantamine	DCJZDG0	Itraconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Galantamine	DCSV26G	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mebutamate + Galantamine	DCJ0DTM	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mefloquine + Galantamine	DCA9AOL	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methocarbamol + Galantamine	DCW8HR1	Methocarbamol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Galantamine	DCIEP2O	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pargyline + Galantamine	DCQCBAV	Pargyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Galantamine	DCTU1WX	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Galantamine	DCLLMJH	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ribavirin-TP + Galantamine	DCFON05	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sitagliptin + Galantamine	DCT6KUP	Sitagliptin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sulfapyridine + Galantamine	DC1KNPI	Sulfapyridine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triapine + Galantamine	DCA12EI	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Trimethobenzamide + Galantamine	DCXCXDI	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
VR-776 + Galantamine	DC18EWA	VR-776	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
WAY-100635 + Galantamine	DCG2Z4N	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Galantamine + Nimodipine	DCVG68K	Nimodipine	Dementia	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6693).
• [2] Galantamine FDA Label
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT00814658) The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life