Details of the Drug Combinations

General Information of This Drug (ID: DMFO843)

Drug Name
Fluspirilene   DMFO843
Synonyms
Fluspirilen; Fluspirileno; Fluspirilenum; Imap; Redeptin; Spirodiflamine; R 6218; F-100; Fluspirileno [INN-Spanish]; Fluspirilenum [INN-Latin]; Imap (TN); Spiropiperidine analogue, 1; Fluspirilene (USAN/INN); Fluspirilene [USAN:INN:BAN]; McN-JR-6218; 1-Phenyl-4-oxo-8-(4,4-bis(4-fluorophenyl)butyl)-1,3,8-triazaspiro(4,5)decane; 8-(4,4-Bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro-(4.5)decan-4-one; 8-[4,4-bis (p-fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4,5]decan-4-one; 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; 8-[4,4-bis(4-fluorophenyl)butyl]-4-phenyl-2,4,8-triazaspiro[4.5]decan-1-one; 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one
Indication
Disease Entry ICD 11 Status REF
Schizophrenia 6A20 Approved [1]
Therapeutic Class
Antipsychotic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

59 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
10-hydroxycamptothecin + Fluspirilene DCNA89B 10-hydroxycamptothecin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Anamorelin + Fluspirilene DCCG7BX Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Fluspirilene DCC1XSR Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Fluspirilene DCKNLNA BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Fluspirilene DCWJ99I Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Fluspirilene DCFRVNC Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorambucil + Fluspirilene DCEGX7O Chlorambucil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cinacalcet + Fluspirilene DCHIDZ8 Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cisatracurium + Fluspirilene DC4G9VI Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Fluspirilene DCWF9FW Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diazoxide + Fluspirilene DCBDBQ2 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dopamine + Fluspirilene DC8BTU7 Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dronedarone + Fluspirilene DCXPJM3 Dronedarone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Flavonoid derivative 1 + Fluspirilene DCKUHFG Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Dantrolene DCOH2N5 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Dactinomycin DC4EOZB Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Fomepizole DCDDOOE Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Chlorzoxazone DCVL6IT Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Metformin DCVCS7D Metformin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Docetaxel DC7RH78 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Armodafinil DC9Z82C Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Clopidogrel DCDD45C Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Pentamidine DCCVM3O Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Trifluoperazine DCA0JR6 Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Tamoxifen DCFX3ZH Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Entacapone DCJRM94 Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Pramipexole DCHFBYO Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Artemisinin DCFXT08 Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Artemisinin DCQEQ0Q Artemisinin DD2 (Cell Line: DD2) [2]
Fluspirilene + Maprotiline DCITPHK Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Amantadine DCY1TS0 Amantadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Chloroquine DCOFCRN Chloroquine DD2 (Cell Line: DD2) [2]
Fluspirilene + Quinine DC7UADO Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Mycophenolic acid DCMJ5DL Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Nabilone DC78NCU Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Sumatriptan DCP7UQ6 Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Chloroquine DCV1J6E Chloroquine Hepatoblastoma (Cell Line: HB3) [3]
Gefitinib + Fluspirilene DC74C1H Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GS4071 + Fluspirilene DCNSVEE GS4071 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Idarubicin + Fluspirilene DCWO03R Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imipramine + Fluspirilene DCQLMRE Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Isosorbide dinitrate + Fluspirilene DC36TNV Isosorbide dinitrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Fluspirilene DCNNWBA IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Fluspirilene DC5XWQ3 Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mebutamate + Fluspirilene DCTCI5W Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + Fluspirilene DCLWG40 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Fluspirilene DCWQS43 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Fluspirilene DCI5IEN Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pazopanib + Fluspirilene DCS62DN Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Fluspirilene DCSKXWQ Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + Fluspirilene DC5EYLV PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Primidone + Fluspirilene DC9J7EJ Primidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sorafenib + Fluspirilene DCEW953 Sorafenib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + Fluspirilene DCKEEK4 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolvaptan + Fluspirilene DCIT1O8 Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + Fluspirilene DCNVYW9 Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tranexamic acid + Fluspirilene DCCHJLO Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trioxsalen + Fluspirilene DCYMLQY Trioxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Valproic Acid + Fluspirilene DCVQVSF Valproic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 59 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 85).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.