Details of the Drug Combinations

General Information of This Drug (ID: DMFTTMK)

• Drug Name: Edivoxetine (DMFTTMK)
• Synonyms: LY2216684

Indication

Major depressive disorder; ICD 11: 6A70.3; Status: Phase 3 [1]; Pediatric attention deficit hyperactivity disorder; ICD 11: 6A05; Status: Phase 3 [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

7 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Clarithromycin + Edivoxetine	DCUACCN	Clarithromycin	Depressive Disorder, Major	[2]
Edivoxetine + Fluoxetine	DC2JFQ5	Fluoxetine	Major Depressive Disorder	[3]
Edivoxetine + Clopidogrel	DCBBQ0A	Clopidogrel	Major Depressive Disorder	[4]
Edivoxetine + Theophylline	DCBOG3F	Theophylline	Major Depressive Disorder	[5]
Edivoxetine + Warfarin	DCOF722	Warfarin	Major Depressive Disorder	[6]
Edivoxetine + Digoxin	DCU3OR1	Digoxin	Major Depressive Disorder	[7]
Sertraline + Edivoxetine	DCPX8P7	Sertraline	Major Depressive Disorder	[8]

References

• [1] ClinicalTrials.gov (NCT01370499) A Study of LY2216684 in Patients With Major Depression Disorder. U.S. National Institutes of Health.
• [2] ClinicalTrials.gov (NCT01460407) A Study to Evaluate the Effect of Clarithromycin on LY2216684
• [3] ClinicalTrials.gov (NCT01243957) A Study to Measure if There is Any Difference in How the Body Breaks Down or Inactivates Either Fluoxetine or LY2216684 When Both of These Medicines Are Given Together.
• [4] ClinicalTrials.gov (NCT01263093) A Pharmacokinetic Study on the Effect of LY2216684 on the Active Metabolite of Clopidogrel
• [5] ClinicalTrials.gov (NCT01263106) A Study of LY2216684 and Theophylline in Healthy Subjects
• [6] ClinicalTrials.gov (NCT01263119) A Study of LY2216684 and Warfarin in Healthy Subjects
• [7] ClinicalTrials.gov (NCT01266590) A Study of LY2216684 and Digoxin in Healthy Subjects
• [8] ClinicalTrials.gov (NCT01250873) A Pharmacokinetic Study of the Coadministration of LY2216684 With Sertraline