Details of the Drug Combinations

General Information of This Drug (ID: DMGHLG5)

Drug Name
Withaferin A   DMGHLG5
Synonyms Heat shock factor 1 inhibitor (melanoma), University of Kansas; HSF-1 inhibitor (melanoma), University of Kansas
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Terminated [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

18 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + Withaferin A DCEUQY6 (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
GDC-0084 + Withaferin A DCMJQUT GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
MK-2206 + Withaferin A DCCM5KM MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
Vincristine + Withaferin A DC5U7HT Vincristine Hodgkin lymphoma (Cell Line: L-1236) [2]
Withaferin A + Ruxolitinib DCJ0KR2 Ruxolitinib T-cell leukemia/lymphoma (Cell Line: ED-40515) [2]
Withaferin A + AT13387 DC3AAJQ AT13387 Ewing sarcoma (Cell Line: TC-71) [2]
Withaferin A + Panobinostat DCPS2RO Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
Withaferin A + Everolimus DCRYHSA Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Withaferin A + Daporinad DCMUALI Daporinad Ewing sarcoma (Cell Line: TC-71) [2]
Withaferin A + Marizomib DCWRQJF Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Withaferin A + Mitomycin DC631XG Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Withaferin A + OSI-906 DCJABLV OSI-906 Ewing sarcoma (Cell Line: TC-71) [2]
Withaferin A + SNX-5422 DCYSLOQ SNX-5422 Ewing sarcoma (Cell Line: TC-71) [2]
Withaferin A + Pelitinib DCUPUI3 Pelitinib Ewing sarcoma (Cell Line: TC-71) [2]
Withaferin A + AXL-1717 DC6KW5I AXL-1717 Ewing sarcoma (Cell Line: TC-71) [2]
Withaferin A + Ruxolitinib DC9TFIC Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
Withaferin A + Fomepizole DCFYDHH Fomepizole Hodgkin lymphoma (Cell Line: L-1236) [3]
Withaferin A + Azathioprine DCI55UN Azathioprine Hodgkin lymphoma (Cell Line: L-1236) [3]
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⏷ Show the Full List of 18 DrugCom(s)

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006527)
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.