Details of the Drug Combinations

General Information of This Drug (ID: DMH6NG5)

Drug Name

FENDILINE DMH6NG5

Synonyms

fendiline; Fendilin; 13042-18-7; Fendilinum; Fendilinum [INN-Latin]; Fendilina [INN-Spanish]; Fendiline [INN]; EINECS 235-915-6; CHEMBL254832; Fendiline (INN); Benzenepropanamine, gamma-phenyl-N-(1-phenylethyl)-; Benzenepropanamine, .gamma.-phenyl-N-(1-phenylethyl)-; 3,3-diphenyl-N-(1-phenylethyl)propan-1-amine; Phendilin; Fendilina; Senzit; NCGC00018223-06; SPBio_001131; Spectrum_000443; AC1L1FPB; Spectrum5_001302; Spectrum2_001006; Prestwick1_000270; Spectrum4_000417; Prestwick3_000270; Spectrum3_001436; Prestwick2_000270

Indication

Disease Entry	ICD 11	Status	REF
Coronary artery disease	BA80	Withdrawn from market	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

8 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Artemisinin + Fendiline	DC2HYFK	Artemisinin	DD2 (Cell Line: DD2)	[2]
Chloroquine + Fendiline	DC0ZGX4	Chloroquine	Hepatoblastoma (Cell Line: HB3)	[2]
Fendiline + Lumefantrine	DC27FPP	Lumefantrine	DD2 (Cell Line: DD2)	[2]
Fendiline + Diltiazem	DCA5EWQ	Diltiazem	DD2 (Cell Line: DD2)	[2]
Fendiline + Artemisinin	DCNYKDU	Artemisinin	DD2 (Cell Line: DD2)	[2]
Fendiline + Mefloquine	DCX28PT	Mefloquine	DD2 (Cell Line: DD2)	[2]
Fendiline + Lumefantrine	DCP3BN7	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
Fendiline + Piperaquine	DCSTU4Q	Piperaquine	Hepatoblastoma (Cell Line: HB3)	[3]
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⏷ Show the Full List of 8 DrugCom(s)

References

1	Value of fendiline in the treatment of patients with stable angina pectoris. Pol Tyg Lek. 1987 Nov 16;42(46):1456-8.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.