Details of the Drug Combinations

General Information of This Drug (ID: DMHN027)

• Drug Name: Levothyroxine (DMHN027)
• Synonyms: Eltroxin; Euthyrox; Forthyron; Laevothyroxinum; Laevoxin; Levolet; Levothroid; Levothyrox; Levothyroxin; Levoxyl; Oroxine; Synthroid; THX; Tetraiodothyronine; Thyratabs; Thyrax; Thyreoideum; Thyroxevan; Thyroxin; Thyroxinal; Levothyroxine sodium; Synthroid sodium; Thyroxine [BAN]; Thyroxine iodine; LT00440967; T4 levothyroxine; DL-Thyroxin; Eltroxin (TN); Euthyrox (TN); Eutirox (TN); Forthyron (TN); L-Thryoxin; L-Thyroxin; L-thyroxine; Laevothyroxinum (acid); Levaxin (TN); Levo-T; Levothyroxine (BAN); Levothyroxinum (acid); Levoxyl (TN); Synthroid (TN); T-3850; T4 (Hormone); Thyrax (TN); Thyrox (TN); Thyroxine (VAN); Thyroxine (l); L-thyroxine (TN); Levothyroxine Sodium (L-thyroxine); Levothroid (*Sodiumsalt*); Synthroid (*Sodium salt*); Thyroxine, L-(8CI); L-3,5,3',5'-Tetraiodothyronine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; Beta-((3,5-Diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl)alanine; O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine; O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine; (-)-Thyroxine; (125I)T4; (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid; 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propanoic acid; 3,3',5,5"-Tetraiodo-L-thyronine; 3,3',5,5''-Tetraiodo-L-thyronine; 3,3',5,5'-Tetraiodo-L-thyronine; 3,5,3',5'-Tetraiodo-L-thyronine; 3,5,3',5'-Tetraiodothyronine; 3,5,3'5'-Tetraiodo-L-thyronine; 3-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)alanine; 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine; 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine

Indication

Congenital hypothyroidism; ICD 11: N.A.; Status: Approved [1]; Edema; ICD 11: MG29; Status: Approved [1]; Goiter; ICD 11: N.A.; Status: Approved [1]; Hashimoto thyroiditis; ICD 11: N.A.; Status: Approved [1]; Hyperlipidemia; ICD 11: 5C80.Z; Status: Approved [1]; Hypothyroidism; ICD 11: 5A00; Status: Approved [2]; Thyroid cancer; ICD 11: 2D10; Status: Approved [1]

• Therapeutic Class: Antithyroid Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Levothyroxine + Methylprednisolone	DCBGKQH	Methylprednisolone	Brain Death	[3]
Liothyronine + Levothyroxine	DC3GBOE	Liothyronine	Hypothyroidism	[4]
Propylthiouracil + Levothyroxine	DCMBRZA	Propylthiouracil	Paediatric Thyrotoxicosis	[5]
Liothyronine + Levothyroxine	DCS5BIQ	Liothyronine	Thyroid Goiter	[6]

References

• [1] Levothyroxine FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4627).
• [3] ClinicalTrials.gov (NCT04528797) Thyroid and Adrenocortical Hormone Replacement in Organ Donors
• [4] ClinicalTrials.gov (NCT00488644) Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors
• [5] ClinicalTrials.gov (NCT01436994) Antithyroid Drug Treatment of Thyrotoxicosis in Young People
• [6] ClinicalTrials.gov (NCT04782856) Energy Metabolism in Thyroidectomized Patients