General Information of This Drug (ID: DMI4EL5)

Drug Name
Ketorolac   DMI4EL5
Synonyms
Ketoralac; Ketorolaco; Ketorolacum; Macril; Ketorolaco [Spanish]; Ketorolacum [Latin]; RS 37619; Acular (TN); Ketorolac (INN); Ketorolac [INN:BAN]; RS-37619; Toradol (TN); (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; (+-)-Ketorolac; (+-)-isomer; (+/-)-2,3-Dihydro-5-benzoyl-1H-pyrrolizine-1-carboxylic acid; 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro; 5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; 5-Benzoyl-1,2-dihydro-3H-pyrrolo(1,2a)pyrrole-1-carboxylic acid; 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Postoperative inflammation 1A00-CA43.1 Approved [1]
Therapeutic Class
Analgesics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Ketorolac + Idarubicin DCRMZU8 Idarubicin Glioblastoma? (Cell Line: T98G) [2]
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27 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Aspirin + Ketorolac DCVG0VA Aspirin Postoperative Pain, Acute [3]
Celecoxib + Ketorolac DCKKNTT Celecoxib Postoperative Pain, Acute [3]
Dexamethasone + Ketorolac DCM9R3V Dexamethasone Chronic Migraine [4]
Ibuprofen + Ketorolac DCCOSP4 Ibuprofen Chronic Pelvic Pain [5]
Ketorolac + Ropivacaine DCE4X4G Ropivacaine Secondary Malignant Neoplasm of Liver [6]
Ketorolac + Ropivacaine DCRDAAC Ropivacaine Secondary Malignant Neoplasm of Liver [6]
Ketorolac + Tramadol DCDPW4T Tramadol Arthritis Knee [7]
Ketorolac + Acetaminophen DC03JMT Acetaminophen Perforated Appendicitis [8]
Ketorolac + Oxycodone DC78RZ0 Oxycodone Arthrodesis [9]
Metoclopramide + Ketorolac DCZB71G Metoclopramide Probable Migraine [10]
Prochlorperazine + Ketorolac DC9DCHC Prochlorperazine Migraine [11]
Ibuprofen + Ketorolac DCCWSQE Ibuprofen Preeclampsia Severe [12]
Ketamine + Ketorolac DCN8JGT Ketamine Pain Management [13]
Ketorolac + Acetaminophen DCQ71Q5 Acetaminophen Irreversible Pulpitis [14]
Pregabalin + Ketorolac DC44LL8 Pregabalin Pain, Postoperative [15]
Prochlorperazine + Ketorolac DCCCD3W Prochlorperazine Headache, Migraine [16]
Ketorolac + Lidocaine DC3KLDA Lidocaine Postoperative Pain [17]
Dexamethasone + Ketorolac DCGGPCM Dexamethasone Obstructive Sleep Apnea [18]
Epinephrine + Ketorolac DC5GTK4 Epinephrine Osteoarthritis of the Knee [19]
Epinephrine + Ketorolac DC5KV9L Epinephrine Osteoarthritis [20]
Epinephrine + Ketorolac DCBOIVX Epinephrine Pain [21]
Fentanyl + Ketorolac DCRY4MD Fentanyl Pain, Postoperative [22]
Gabapentin + Ketorolac DC1JR7L Gabapentin Pain [23]
Ketorolac + Lidocaine DC487K6 Lidocaine Pain [24]
Ketorolac + Acetaminophen DCPCDIP Acetaminophen Postoperative Pain [25]
Ketorolac + Ropivacaine DCQE80O Ropivacaine Pain [26]
Levobupivacaine + Ketorolac DCX6GZ8 Levobupivacaine Total Knee Arthroplasty [27]
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⏷ Show the Full List of 27 DrugCom(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 ClinicalTrials.gov (NCT05994287) Pain Treatment With Combinations of NSAIDs
4 ClinicalTrials.gov (NCT04353505) Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache
5 ClinicalTrials.gov (NCT01514175) A Pilot Study Comparing the Analgesic Efficacy of IV Ibuprofen and IV Ketorolac
6 ClinicalTrials.gov (NCT02647047) Spinal Versus Epidural Analgesia in Laparotomic Liver Surgery
7 ClinicalTrials.gov (NCT06112548) The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA
8 ClinicalTrials.gov (NCT02881996) The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
9 ClinicalTrials.gov (NCT05054868) Ketorolac vs Oxycodone for Great Toe Arthrodesis
10 ClinicalTrials.gov (NCT01596166) Intravenous Ketorolac and Metoclopramide for Pediatric Migraine in the Emergency Department
11 ClinicalTrials.gov (NCT06182098) Intravenous Fluids in Pediatric Migraine
12 ClinicalTrials.gov (NCT03978767) Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial
13 ClinicalTrials.gov (NCT05597878) Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy
14 ClinicalTrials.gov (NCT02614118) Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain
15 ClinicalTrials.gov (NCT03669081) Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy
16 ClinicalTrials.gov (NCT06083571) Intranasal Ketorolac Trial
17 ClinicalTrials.gov (NCT03485625) Adjuncts to IVRA, a Comparison Between Ketorolac and Paracetamol
18 ClinicalTrials.gov (NCT03467750) Effect of Ketorolac on Post Adenotonsillectomy Pain
19 ClinicalTrials.gov (NCT00562627) Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty
20 ClinicalTrials.gov (NCT02658149) Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty
21 ClinicalTrials.gov (NCT04141319) Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain
22 ClinicalTrials.gov (NCT02653742) Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children
23 ClinicalTrials.gov (NCT02867176) Pain Management in Corneal Collagen Crosslinking for Keratoconus
24 ClinicalTrials.gov (NCT02902770) Intravenous Lidocaine and Ketorolac for Pain Management
25 ClinicalTrials.gov (NCT02313675) Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries
26 ClinicalTrials.gov (NCT02829944) Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery
27 ClinicalTrials.gov (NCT02082067) Total Knee Prosthesis With Continuous Block of Adductor Canal and Outcome