Details of the Drug Combinations

General Information of This Drug (ID: DMIMF8J)

Drug Name

Risdiplam DMIMF8J

Synonyms

UNII-76RS4S2ET1; 76RS4S2ET1; 1825352-65-5; Risdiplam [INN]; SCHEMBL17260852; EX-A2074; RG-7916; HY-109101; RO7034067; CS-0039501; 4H-Pyrido(1,2-a)pyrimidin-4-one, 7-(4,7-diazaspiro(2.5)oct-7-yl)-2-(2,8-dimethylimidazo(1,2-b)pyridazin-6-yl)-; 2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

Indication

Disease Entry	ICD 11	Status	REF
Spinal muscular atrophy	8B61	Approved	[1]
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Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Itraconazole + Risdiplam	DC2TBRF	Itraconazole	Spinal Muscular Atrophy	[2]
Omeprazole + Risdiplam	DC37YLX	Omeprazole	Muscular Atrophy, Spinal	[3]
Risdiplam + Midazolam	DCGWN5E	Midazolam	Spinal Muscular Atrophy	[4]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
2	ClinicalTrials.gov (NCT02633709) A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) Given by Mouth in Healthy Volunteers
3	ClinicalTrials.gov (NCT04718181) Bioavailability and Bioequivalence of Two Risdiplam Tablets in Healthy Participants
4	ClinicalTrials.gov (NCT03988907) A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants