Details of the Drug Combinations

General Information of This Drug (ID: DMJDYNQ)

Drug Name

E-2007 DMJDYNQ

Synonyms

Perampanel; E 2007; Perampanel (USAN); 2-(2-oxo-1-phenyl-5-pyridin-2-yl-pyridin-3-yl)benzonitrile; 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one

Indication

Disease Entry	ICD 11	Status	REF
Diabetic neuropathy	8C0Z	Approved	[1]
Parkinson disease	8A00.0	Discontinued in Phase 3	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Disulfiram + E-2007	DC31U6E	Disulfiram	Alcohol Disorders	[2]
Ketamine + E-2007	DCY4FMV	Ketamine	Depressive Disorder, Major	[3]
Ketamine + E-2007	DCYE9F0	Ketamine	Depressive Disorder	[4]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7050).
2	ClinicalTrials.gov (NCT04502589) Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder
3	ClinicalTrials.gov (NCT03367533) Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
4	ClinicalTrials.gov (NCT05786066) The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects