Details of the Drug Combinations

General Information of This Drug (ID: DMJIBAW)

• Drug Name: Budesonide (DMJIBAW)
• Synonyms: Bidien; Budenofalk; Budeson; Budesonido; Budesonidum; Budiair; Cortivent; Entocort; Horacort; Inflammide; Micronyl; Miflonide; Preferid; Pulmaxan; Respules; Rhinocort; Spirocort; UDB; Budecort Inhaler; Budesonide Easyhaler; Budesonide MMX; Entocort EC; GionaEasyhaler; Pulmaxan turbohaler; Pulmicort Flexhaler; Pulmicort Nebuamp; Pulmicort Respules; Pulmicort Topinasal; Pulmicort turbuhaler; Rhinocort Aqua; Rhinocort Turbuhaler; Rhinocort alpha; Unit dosebudesonide; B 7777; S 1320; Budesonido [INN-Spanish]; Budesonidum [INN-Latin]; Entocort (TN); Entocort EC (TN); MAP-0010; Noex (TN); Pulmicort (TN); Rhinocort (TN); S-1320; Budesonide (JAN/USAN/INN); Budesonide [USAN:INN:BAN:JAN]; Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide; Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-,and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione; (11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione; (11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione; (4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; (R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde; (RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione; (RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde; (S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione; 11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione; 16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione; 16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione; 16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione; 16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione; 16alpha-,17alpha-butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione

Indication

Allergic rhinitis; ICD 11: CA08.0; Status: Approved [1]; Asthma; ICD 11: CA23; Status: Approved [2]; Crohn disease; ICD 11: DD70; Status: Approved [1]; Inflammatory bowel disease; ICD 11: DD72; Status: Approved [1]; Radiation proctitis; ICD 11: N.A.; Status: Approved [1]; Ulcerative colitis; ICD 11: DD71; Status: Approved [1]; Coronavirus Disease 2019 (COVID-19); ICD 11: 1D6Y; Status: Phase 3 [3]

• Therapeutic Class: Antiinflammatory Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Budesonide + Ruxolitinib	DC2UOGM	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[4]

14 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Budesonide + Montelukast	DC3E7D3	Montelukast	Obstructive Sleep Apnea Syndrome	[5]
Budesonide + Theophylline	DC5BCNZ	Theophylline	Chronic Obstructive Pulmonary Disease	[6]
Budesonide + Montelukast	DCMZHJ2	Montelukast	Asthma	[7]
Budesonide + Azelastine	DCVUCUR	Azelastine	Allergic Rhinitis	[8]
Micafungin + Budesonide	DCS52DE	Micafungin	Stem Cell Transplantation	[9]
Povidone-iodine + Budesonide	DC04HQH	Povidone-iodine	Chronic Rhinosinusitis (Diagnosis)	[10]
Procaterol + Budesonide	DCJ3BHD	Procaterol	Asthma	[11]
Budesonide + Formoterol	DCIRMI3	Formoterol	Coronavirus Disease 2019 (COVID-19)	[12]
HKI-272 + Budesonide	DCM4LRJ	HKI-272	Early Stage HER2+ Breast Cancer	[13]
Beclomethasone dipropionate + Budesonide	DC7YHXU	Beclomethasone dipropionate	Chronic Obstructive Pulmonary Disease	[14]
Doxofylline + Budesonide	DCDARLY	Doxofylline	Asthma Chronic	[15]
Budesonide + Budesonide	DC2V2GF	Budesonide	Severe IgE-mediated Asthma	[16]
Budesonide + Mycophenolate mofetil	DCWSC1S	Mycophenolate mofetil	Acute Cellular Graft Rejection	[17]
Budesonide + Methylprednisolone	DCOT1P1	Methylprednisolone	Chronic Obstructive Pulmonary Disease	[18]

1 Approved Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Budesonide + Formoterol	DC45N8S	Formoterol	Asthma	[19]

References

• [1] Budesonide FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7434).
• [3] Inhaled Corticosteroid Treatment of COVID19 Patients With Pneumonia
• [4] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [5] ClinicalTrials.gov (NCT00912171) Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children
• [6] ClinicalTrials.gov (NCT00634413) Effect of ADC4022 Co-Administered With Budesonide on Pulmonary Inflammation in Subjects With Moderate to Severe COPD
• [7] ClinicalTrials.gov (NCT00462592) Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
• [8] ClinicalTrials.gov (NCT04561687) Comparison of Montelukast and Azelastine in Treatment of Moderate to Severe Allergic Rhinitis
• [9] ClinicalTrials.gov (NCT01950507) Evaluation of Budesonide and How It Interacts With Antifungal Drugs in People With Gastrointestinal Graft-Versus-Host Disease
• [10] ClinicalTrials.gov (NCT04097613) Betadine Rinses for Chronic Rhinosinusitis Prospective Cohort Study
• [11] ClinicalTrials.gov (NCT02165046) Bioavailability Study of SYN006, Pulmicort pMDI and Meptin Air in Healthy Adult.
• [12] ClinicalTrials.gov (NCT04331470) Evaluation of Efficacy of Levamisole and Formoterol+Budesonide in Treatment of COVID-19. U.S. National Institutes of Health.
• [13] ClinicalTrials.gov (NCT02400476) An Open-Label Study to Characterize the Incidence and Severity of Diarrhea in Patients With Early-Stage HER2+ Breast Cancer Treated With Neratinib and Loperamide
• [14] ClinicalTrials.gov (NCT00476099) Efficacy and Safety Study of Beclometasone/Formoterol Single Inhaler in Patients With COPD
• [15] ClinicalTrials.gov (NCT03879590) Efficacy Of Doxophylline As A Sparing Treatment For Inhaled Corticosteroids In Mexican Children With Asthma
• [16] ClinicalTrials.gov (NCT01912872) Study to Assess the Efficacy and Safety of Omalizumab Treatment on ICS Reduction for Severe IgE-mediated Asthma
• [17] ClinicalTrials.gov (NCT03315052) Budesonide for Immunosuppression After Liver Transplantation to Reduce Side Effects
• [18] ClinicalTrials.gov (NCT01865500) Two Different Dosages of Nebulized Steroid Versus Parenteral Steroid in the Management of COPD Exacerbations
• [19] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015