Details of the Drug Combinations

General Information of This Drug (ID: DMJOQM3)

Drug Name

Eflornithine DMJOQM3

Synonyms

EFLORNITHINE; Ornidyl; 70052-12-9; 2-(Difluoromethyl)ornithine; alpha-Difluoromethylornithine; Difluromethylornithine; Eflornitina [Spanish]; Eflornithinum [Latin]; 2,5-diamino-2-(difluoromethyl)pentanoic acid; alpha-(Difluoromethyl)-DL-ornithine; N-Difluoromethylornithine; DFMO (growth regulator); 67037-37-0; Eflornithine [INN:BAN]; 2-(Difluoromethyl)-DL-ornithine; DL-alpha-(Difluoromethyl)ornithine; MDL 71782; CCRIS 3295; Ornithine, 2-(difluoromethyl)-; Eflornithinum; Eflornitina; DFMO hydrochloride; DFMO hydrochloride hydrate; EFLORNITHINE HYDROCHLORIDE; BMS 203522; Alpha-DFMO HCl; Alpha-Difluoromethylornithine; Alpha-Difluoromethylornithine hydrochloride; CPP-1X; Eflornithine (INN); Ornidyl (TN); DL-alpha-Difluoromethylornithine; DL-alpha-Difluoromethylornithine hydrochloride hydrate; D,L-alpha-Difluoromethylornithine; Alpha-(Difluoromethyl)-DL-ornithine; Alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid; Ornithine, 2-(difluoromethyl)-, monohydrochloride; DL-Ornithine, 2-(difluoromethyl)-, monohydrochloride; DL-Ornithine, 2-(difluoromethyl)-, monohydrochloride, monohydrate; 2,5-diamino-2-(difluoromethyl)pentanoic acid hydrochloride; 2-(Difluoromethyl)-DL-ornithine HCl; 2-(Difluoromethyl)-DL-ornithine hydrochloride; 2-(Difluoromethyl)-DL-ornithine monohydrochloride; 2-(Difluoromethyl)ornithine hydrochloride hydrate

Indication

Disease Entry	ICD 11	Status	REF
African trypanosomiasis	1F51	Approved	[1]
Trypanosomiasis	1D51-1F53	Phase 2	[2]
Colon cancer	2B90.Z	Investigative	[3]
Familial adenomatous polyposis	2B90.Y	Investigative	[3]
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Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

66 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acetohexamide + Eflornithine	DCHSM83	Acetohexamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Aliskiren + Eflornithine	DCCL7EP	Aliskiren	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Allopurinol + Eflornithine	DCBQ70I	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
BIO-300 + Eflornithine	DCAWLY9	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Bortezomib + Eflornithine	DC0I0BU	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
BRL-15572 + Eflornithine	DCHOYPK	BRL-15572	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Cilostazol + Eflornithine	DCAXJX0	Cilostazol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Cinacalcet + Eflornithine	DCZD9P6	Cinacalcet	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Clascoterone + Eflornithine	DCO1MVH	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Cytarabine + Eflornithine	DCUJHJR	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Dantrolene + Eflornithine	DC3NK95	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Diethylcarbamazine + Eflornithine	DC3V3N3	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Ribavirin-TP	DC2XM0D	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Vinblastine	DCUJ0LF	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Anamorelin	DCM68XL	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Acitretin	DCO3IJL	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + 10-hydroxycamptothecin	DCA5326	10-hydroxycamptothecin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + IT-141	DCZYNSR	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Emetine	DCGKB0P	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Chlorzoxazone	DC88QIZ	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Docetaxel	DCHW2YX	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Pazopanib	DCUBLEX	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Tolazoline	DC39C70	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Tiagabine	DCLMXNJ	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Ibutilide	DCDO49H	Ibutilide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Entacapone	DCT3P30	Entacapone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Idarubicin	DC4UWBA	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Linagliptin	DCSTA9G	Linagliptin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Artemisinin	DCVOXCE	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Trimethobenzamide	DCIP3XV	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Oxyphenbutazone	DC8FMP1	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Acarbose	DCLW538	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Brincidofovir	DCP5KKG	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Asenapine	DCSV3DR	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Quinine	DCO2UWP	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Endoxifen	DCWT8GN	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Mycophenolic acid	DCXP4QZ	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Doxorubicin	DC8YBPH	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Sumatriptan	DCPG96E	Sumatriptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Eflornithine + Tetracycline	DCNXII6	Tetracycline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Epinephrine + Eflornithine	DCU7CWX	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Hydralazine + Eflornithine	DC03FDS	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Imatinib + Eflornithine	DC7YRFB	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Kanamycin + Eflornithine	DCQDFYL	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Leflunomide + Eflornithine	DC6X3W1	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Lumefantrine + Eflornithine	DCYLHB3	Lumefantrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Maprotiline + Eflornithine	DC06UG7	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Mefloquine + Eflornithine	DCO3RTB	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Memantine + Eflornithine	DCQ85OV	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Methotrexate + Eflornithine	DCXJ6F2	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Metyrosine + Eflornithine	DC1Z32P	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Mycophenolic acid + Eflornithine	DCPZWAA	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Niclosamide + Eflornithine	DCWHLTZ	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Olmesartan medoxomil + Eflornithine	DCUN62D	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Pazopanib HCl + Eflornithine	DCG1G5N	Pazopanib HCl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Pepstatin + Eflornithine	DC3MHCM	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
PFK-158 + Eflornithine	DCIB7S7	PFK-158	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Phensuximide + Eflornithine	DC1ZMIC	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
PMID28460551-Compound-2 + Eflornithine	DCD5HXF	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Pyrazinamide + Eflornithine	DC18XVL	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Tamoxifen + Eflornithine	DCR0ZCH	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Theophylline + Eflornithine	DCOF40E	Theophylline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Triiodothyronine + Eflornithine	DCH1JIC	Triiodothyronine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Trimethobenzamide + Eflornithine	DC4A7QI	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Vorinostat + Eflornithine	DCCYHT2	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Zaleplon + Eflornithine	DCI0AOK	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
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⏷ Show the Full List of 66 DrugCom(s)

10 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aspirin + Eflornithine	DCOLXYT	Aspirin	Adenomatous Polyp	[5]
Celecoxib + Eflornithine	DCOI4EP	Celecoxib	Colorectal Cancer	[6]
Eflornithine + Bicalutamide	DCONSG6	Bicalutamide	Prostate Cancer	[7]
Eflornithine + Nifurtimox	DCQDAKR	Nifurtimox	Human African Trypanosomiasis (HAT)	[8]
Eflornithine + Bortezomib	DC4MD8M	Bortezomib	Neuroblastoma Recurrent	[9]
Eflornithine + Temozolomide	DCUW4KF	Temozolomide	Glioblastoma, IDH-wildtype	[10]
Etoposide + Eflornithine	DCJH6BL	Etoposide	Neuroblastoma	[11]
Sulindac + Eflornithine	DCQKAQ0	Sulindac	Precancerous Condition	[12]
Sulindac + Eflornithine	DC91WUV	Sulindac	Familial adenomatous polyposis; Colon cancer	[13]
Eflornithine + Lomustine	DCODY56	Lomustine	Anaplastic Astrocytoma	[14]
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⏷ Show the Full List of 10 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5176).
2	ClinicalTrials.gov (NCT01636128) Urinary Biomarker Study With Sulindac and Difluoromethylornithine. U.S. National Institutes of Health.
3	Eflornithine FDA Label
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	ClinicalTrials.gov (NCT00983580) Acetylsalicylic Acid and Eflornithine in Treating Patients at High Risk for Colorectal Cancer
6	ClinicalTrials.gov (NCT00033371) Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous Polyposis
7	ClinicalTrials.gov (NCT00086736) Neoadjuvant Eflornithine and Bicalutamide Compared With Eflornithine Alone, Bicalutamide Alone, and No Neoadjuvant Therapy in Treating Patients With Localized Prostate Cancer Undergoing Brachytherapy or Radical Prostatectomy
8	ClinicalTrials.gov (NCT01685827) Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2
9	ClinicalTrials.gov (NCT02139397) Study of Difluoromethylornithine (DFMO) in Combination With Bortezomib for Relapsed or Refractory Neuroblastoma
10	ClinicalTrials.gov (NCT05879367) Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma
11	ClinicalTrials.gov (NCT01059071) Safety Study for Refractory or Relapsed Neuroblastoma With DFMO Alone and in Combination With Etoposide
12	ClinicalTrials.gov (NCT00118365) Eflornithine and Sulindac in Preventing Colorectal Cancer in Patients With Colon Polyps
13	FDA Drug Development and Drug Interactions
14	ClinicalTrials.gov (NCT02796261) Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients