Details of the Drug Combinations

General Information of This Drug (ID: DMKA8J4)

Drug Name
Etonogestrel   DMKA8J4
Synonyms
Etonogestrelum; Implanon; Implanon (TN); NuvaRing (TN); Etonogestrel (USAN/INN); (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one; 17alpha-ethynyl-17beta-hydroxy-11-methylidene-18a-homo-estr-4-en-3-one; 3-Ketodesogestrel; 3-Oxodesogestrel
Indication
Disease Entry ICD 11 Status REF
Contraception QA21 Approved [1]
Therapeutic Class
Contraceptive Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

55 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Aprepitant + Etonogestrel DCOOOLQ Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Etonogestrel DCXFD33 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Etonogestrel DCEVJQ9 Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Etonogestrel DCUUJ5S BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Etonogestrel DCKZLZR Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Etonogestrel DCHJ1KG Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Etonogestrel DC5UPQV Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Etonogestrel DC19OHD Ethambutol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Ribavirin-TP DCF9Z4O Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Gefitinib DC5966U Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Citalopram DCHUMQF Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Epinephrine DCJSOM2 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + PMID28460551-Compound-2 DCOP62W PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Methotrexate DCI6FAE Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Dihydroergotamine DCRRS0R Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Vinblastine DCTCD96 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Triapine DCYAIGX Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + IT-141 DCBWDQ3 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + BHV-0223 DCPK5EO BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Metyrosine DC7QGWC Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Terameprocol DCLDQ2G Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Emetine DCZW408 Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Chlorzoxazone DC3RQB3 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Phenprocoumon DC5CDN9 Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Ginsenoside Rb1 DCH6T4P Ginsenoside Rb1 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Isoproterenol DC9I6R6 Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Idarubicin DC08AVS Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Clascoterone DCR7OVM Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Trimethobenzamide DCB6NT3 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Maprotiline DCMYD2W Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Brincidofovir DC67QJO Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Hyodeoxycholic acid DC14QP1 Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Mycophenolic acid DCMDG58 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Hydralazine DC7NIAI Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Pizotyline DC9C034 Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Sumatriptan DCBIMK0 Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Cerivastatin DCD0YLR Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Enoxacin DC8WM99 Enoxacin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fenoprofen + Etonogestrel DCW210A Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + Etonogestrel DCW1913 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Leflunomide + Etonogestrel DCYQ6Z2 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + Etonogestrel DCWITE8 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Naringenin + Etonogestrel DCQYWDC Naringenin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitrosoglutathione + Etonogestrel DC65CHP Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Oxyphenbutazone + Etonogestrel DC450T7 Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pomalidomide + Etonogestrel DCRMR19 Pomalidomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Etonogestrel DCBFKLA Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Rifampin + Etonogestrel DC36PDT Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tamoxifen + Etonogestrel DCEPJOX Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Teriflunomide + Etonogestrel DCT1TVU Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + Etonogestrel DCGUY02 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trihexyphenidyl + Etonogestrel DCZ6RG4 Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triiodothyronine + Etonogestrel DCCEFIT Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + Etonogestrel DC7NK6T Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trioxsalen + Etonogestrel DC5UDT0 Trioxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 55 DrugCom(s)
3 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Etonogestrel + Estradiol DCBPX0C Estradiol Contraception [3]
Mestranol + Etonogestrel DCHDU6O Mestranol Contraception [3]
Ibuprofen + Etonogestrel DCPJ4JG Ibuprofen Moderate to Severe Primary Dysmenorrhea [4]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7590).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 ClinicalTrials.gov (NCT01709318) A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012)
4 ClinicalTrials.gov (NCT02668783) Efficacy and Safety of Etonogestrel + 17-Estradiol Vaginal Ring (MK-8342B) in Women With Primary Dysmenorrhea (With Optional Extension) (MK-8342B-059)