Details of the Drug Combinations

General Information of This Drug (ID: DMKM5HB)

Drug Name

Sitaxsentan DMKM5HB

Synonyms

Sitaxentan; IPI 1040; TBC 11251; TBC11251; Sitaxentan (INN); TBC-11251; N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((2-methyl-4,5-methylenedioxyphenyl)acetyl)thiophene-3-sulfonamide; N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((3,4-(methylenedioxy)-6-methylphenyl)acetyl)-3-thiophenesulfonamide; N-(4-chloro-3-methyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary arterial hypertension	BB01.0	Withdrawn from market	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Rifampicin + Sitaxsentan	DCCUNQH	Rifampicin	Pulmonary Arterial Hypertension	[2]
Sildenafil + Sitaxsentan	DC3P4O2	Sildenafil	Pulmonary Arterial Hypertension	[3]
Sitaxsentan + Ritonavir	DCSOOKH	Ritonavir	Pulmonary Arterial Hypertension	[4]
Tadalafil + Sitaxsentan	DC7PMTE	Tadalafil	Pulmonary Arterial Hypertension	[3]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3950).
2	ClinicalTrials.gov (NCT01251835) Effect Of Rifampin On Pharmacokinetics Of Sitaxsentan
3	ClinicalTrials.gov (NCT01244620) A Pharmacokinetic Drug-Drug Interaction (DDI) Study Between Sitaxsentan And Sildenafil, And Between Sitaxsentan And Tadalafil After Multiple Doses
4	ClinicalTrials.gov (NCT01251848) Drug Interaction Between Ritonavir And Sitaxsentan