Details of the Drug Combinations

General Information of This Drug (ID: DMKMBES)

Drug Name

Plazomicin DMKMBES

Synonyms

ACHN-490; UNII-LYO9XZ250J; 1154757-24-0; LYO9XZ250J; Plazomicin [USAN:INN]; Plazomicin (USAN); ZINC68150640; DB12615; D10151; D-Streptamine,

Indication

Disease Entry	ICD 11	Status	REF
Bronchitis	CA20	Approved	[1]
Prostate disease	GA91	Approved	[1]
Urinary tract infection	GC08	Approved	[1]
Pancreatic cancer	2C10	Phase 3	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Meropenem + Plazomicin	DCDIRKH	Meropenem	Bloodstream Infections (BSI) Due to CRE	[2]
Plazomicin + Levofloxacin	DC1XYE7	Levofloxacin	Complicated Urinary Tract Infection	[3]
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References

1	In vitro activity of plazomicin against -lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE).J Antimicrob Chemother. 2017 Oct 1;72(10):2792-2795.
2	ClinicalTrials.gov (NCT01970371) A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE). U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT02486627) A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP)