Details of the Drug Combinations

General Information of This Drug (ID: DML60TN)

• Drug Name: Sotalol (DML60TN)
• Synonyms: Sotalolum; Darob mite; Sotalol Monohydrochloride; Beta-Cardone; Betapace (TN); Betapace AF (TN); Darob mite (TN); MJ-1999; Sotacor (TN); Sotalex (TN); Sotalol (INN); Sotalol [INN:BAN]; Sotalolum [INN-Latin]; D,l-Sotalol; N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide; N-(4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}phenyl)methanesulfonamide; N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide; Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-(9CI); 4'-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide; 4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulfonanilid

Indication

Sinus rhythm disorder; ICD 11: BC9Y; Status: Approved [1]

• Therapeutic Class: Antiarrhythmic Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

3 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Sotalol + Panobinostat	DC34DWY	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Sotalol + Lumefantrine	DCIHU9C	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
Sotalol + Chloroquine	DCO13HQ	Chloroquine	Hepatoblastoma (Cell Line: HB3)	[3]

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Sotalol + Dofetilide	DC89SGH	Dofetilide	Atrial Fibrillation	[4]
Sotalol + Amiodarone	DCK5H6M	Amiodarone	Ventricular Tachycardia	[5]
Sotalol + Digoxin	DC851I0	Digoxin	Fetal Atrial Flutter Without Hydrops	[6]
Sotalol + Flecainide	DCI5CRT	Flecainide	Atrial Fibrillation	[7]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7297).
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [4] ClinicalTrials.gov (NCT04128878) Improvement in Endothelial Dysfunction After Initiation of Anti-arrhythmic Therapy in Atrial Fibrillation Patients
• [5] ClinicalTrials.gov (NCT01576042) Pilot Study of Catheter Ablation for Ventricular Tachycardia in Patients With an Implantable Cardioverter Defibrillator
• [6] ClinicalTrials.gov (NCT02624765) Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT)
• [7] ClinicalTrials.gov (NCT02347111) Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation