Details of the Drug Combinations

General Information of This Drug (ID: DMMUOLJ)

Drug Name

Varenicline DMMUOLJ

Synonyms

CP 526555; Champix (TN); Chantix (TN); Varenicline (INN); 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine; 7,8,9,10-tetrahydro-6h-6,10-methanoazepino[4,5-g]quinoxaline

Indication

Disease Entry	ICD 11	Status	REF
Drug dependence	N.A.	Approved	[1]
Smoking dependence	6C4A.2	Approved	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

11 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bupropion + Varenicline	DCY0TDX	Bupropion	Nicotine Dependence	[3]
Bupropion + Varenicline	DC6MWBZ	Bupropion	Nicotine Dependence	[4]
Lorcaserin + Varenicline	DCJ8CV6	Lorcaserin	Tobacco Use Disorder	[5]
Varenicline + Naltrexone	DCBLL76	Naltrexone	Smoking	[6]
Varenicline + Nicotine	DCLVMFC	Nicotine	Nicotine Dependence	[3]
Varenicline + Prazosin	DCRH4DS	Prazosin	Cigarette Smoking	[7]
Lorcaserin + Varenicline	DC3Q0DF	Lorcaserin	Obesity	[8]
Varenicline + Nicotine	DC65DT3	Nicotine	Smoking Cessation	[9]
Varenicline + Acetylcysteine	DCMWC39	Acetylcysteine	Nicotine Dependence, Cigarettes	[10]
Bupropion + Varenicline	DCSWZ7S	Bupropion	Smoking Cessation	[11]
Bupropion + Varenicline	DCVB53E	Bupropion	Smoking Cessation	[12]
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⏷ Show the Full List of 11 DrugCom(s)

References

1	Varenicline FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5459).
3	ClinicalTrials.gov (NCT01406223) Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation
4	ClinicalTrials.gov (NCT00749658) Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence
5	ClinicalTrials.gov (NCT02393547) Lorcaserin for Preventing Weight Gain Among Smokers
6	ClinicalTrials.gov (NCT00502216) Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers
7	ClinicalTrials.gov (NCT02193256) Varenicline + Prazosin for Heavy Drinking Smokers
8	ClinicalTrials.gov (NCT02412631) Addressing Post Cessation Weight Gain
9	ClinicalTrials.gov (NCT05413122) Evaluating Smoking Cessation Interventions for PWH in South Africa
10	ClinicalTrials.gov (NCT02723162) Translational Neuropsychopharmacology Research of Nicotine Addiction
11	ClinicalTrials.gov (NCT03897439) Individualizing Pharmacotherapy for African American Smokers
12	ClinicalTrials.gov (NCT01330043) Extended Treatment for Smoking Cessation