Details of the Drug Combinations

General Information of This Drug (ID: DMMZXIW)

• Drug Name: Rabeprazole (DMMZXIW)
• Synonyms: Dexrabeprazole; Eraloc; Rebeprazole sodium; CL23619; LY307640; Aciphex (TN); Eraloc (TN); Pariet (TN); Rabeprazole (INN); Rabeprazole [BAN:INN]; Rabeprazole [INN:BAN]; Rablet (TN); 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole; 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole; 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole; 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1H-benzimidazole

Indication

Bacterial infection; ICD 11: 1A00-1C4Z; Status: Approved [1]; Gastrinoma; ICD 11: 2C10.1; Status: Approved [2]; Peptic ulcer; ICD 11: DA61; Status: Approved [2]

• Therapeutic Class: Antiulcer Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Rabeprazole + Idarubicin	DCZT7UW	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]

15 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acalabrutinib + Rabeprazole	DCDKVH4	Acalabrutinib	Infectious Disease	[4]
AKB-6548 + Rabeprazole	DCCJ7XS	AKB-6548	Drug Interaction Potentiation	[5]
Clarithromycin + Rabeprazole	DCP9HTK	Clarithromycin	Helicobacter Pylori Infection	[6]
GDC-0152 + Rabeprazole	DC9QRYC	GDC-0152	Amyotrophic Lateral Sclerosis	[7]
Rabeprazole + Amoxicillin	DCCVWWH	Amoxicillin	Helicobacter Pylori Infection	[6]
Rabeprazole + Amoxicillin	DC91EA6	Amoxicillin	Helicobacter Pylori Infection	[8]
Berberine + Rabeprazole	DCMO25P	Berberine	Dyspepsia	[9]
Clarithromycin + Rabeprazole	DCCFCI5	Clarithromycin	Helicobacter Pylori Infection	[10]
Clarithromycin + Rabeprazole	DCJ5WBT	Clarithromycin	Helicobacter Pylori Infection	[10]
Doxycycline + Rabeprazole	DC5VI5Z	Doxycycline	Helicobacter Pylori Infection	[10]
Rabeprazole + Metronidazole	DC0CVYJ	Metronidazole	Helicobacter Pylori Infection	[11]
Rabeprazole + Metronidazole	DC0NGF9	Metronidazole	Helicobacter Pylori Infection	[12]
Rabeprazole + Levofloxacin	DC695L1	Levofloxacin	Helicobacter Pylori Infection	[13]
Rabeprazole + Amoxicillin	DC2DHYZ	Amoxicillin	Helicobacter Pylori Infection	[10]
Rabeprazole + Metronidazole	DCYHMAT	Metronidazole	Helicobacter Pylori Infection	[12]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7290).
• [2] Rabeprazole FDA Label
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT04489797) A Study to Evaluate Effects of Proton-pump Inhibitor on Acalabrutinib Capsule When Administered Orally With COCA-COLA in Healthy Participants
• [5] ClinicalTrials.gov (NCT03789032) Study to Evaluate the Effect of Rabeprazole on the Pharmacokinetics of Vadadustat
• [6] ClinicalTrials.gov (NCT05152004) Efficacies of Hybrid and High-dose Dual Therapies for the First-line Anti-H Pylori Treatment
• [7] ClinicalTrials.gov (NCT02655614) A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis
• [8] ClinicalTrials.gov (NCT06076694) Efficacy and Safety After Multiple Doses of TNP-2198 Capsules, Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules in Helicobacter Pylori Infected-positive Participants
• [9] ClinicalTrials.gov (NCT04697186) Helicobacter Pylori Eradication With Berberine Plus Amoxicillin Triple Therapy Versus Bismuth-containing Quadruple Therapy
• [10] ClinicalTrials.gov (NCT05061732) Helicobacter Pylori Eradication and Follow-up
• [11] ClinicalTrials.gov (NCT05018923) Tetracycline Versus Doxycycline for HP Rescue Therapy
• [12] ClinicalTrials.gov (NCT04667299) Bismuth-Metronidazole Triple Therapy for H. Pylori First-line Treatment
• [13] ClinicalTrials.gov (NCT05023577) Antibiotic Combination for H. Pylori Eradication in Penicillin-allergic Patients