Details of the Drug Combinations

General Information of This Drug (ID: DMNFUZR)

Drug Name

Enalapril DMNFUZR

Synonyms

Vasotec; Enalapril (INN); Enalapril (TN); N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl-L-proline; N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline; (2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Congestive heart failure	BD10	Approved	[1]
Hypertension	BA00-BA04	Approved	[2]
Malignant essential hypertension	BA00	Approved	[1]
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Therapeutic Class

Antihypertensive Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aliskiren + Enalapril	DCGGKY4	Aliskiren	Chronic Heart Failure	[3]
Sitagliptin + Enalapril	DC6T1FG	Sitagliptin	Metabolic Syndrome	[4]
Valsartan + Enalapril	DC2DS8Q	Valsartan	Hypertension	[5]
Labetalol + Enalapril	DCGWYPM	Labetalol	Stroke, Acute	[6]
Clonidine + Enalapril	DC88923	Clonidine	Hypertension	[7]
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References

1	Enalapril FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6322).
3	ClinicalTrials.gov (NCT00853658) Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbidity-mortality in Patients With Chronic Heart Failure
4	ClinicalTrials.gov (NCT00666848) Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome
5	ClinicalTrials.gov (NCT00446511) Extension Study to Assess Long Term Safety, Tolerability, and Efficacy of Valsartan and Enalapril Combined and Alone in Children With Hypertension
6	ClinicalTrials.gov (NCT04484350) Blood Pressure Management in Stroke Following Endovascular Treatment
7	ClinicalTrials.gov (NCT02177461) Telmisartan Compared With Enalapril in Elderly Patients With Blood Hypertension