Details of the Drug Combinations

General Information of This Drug (ID: DMNSJ7V)

Drug Name
Tropisetron   DMNSJ7V
Synonyms
Navoban; Novaban; TKT; ICS-205930; Navoban (TN); Tropisetron (INN); [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylate
Indication
Disease Entry ICD 11 Status REF
Fibromyalgia MG30.01 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

65 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abacavir + Tropisetron DCHFRA7 Abacavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Tropisetron DCAP5RQ Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Tropisetron DCW7REH Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Tropisetron DC1C9WG Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Tropisetron DCFO7CX BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Tropisetron DCNB7EX Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Tropisetron DCBD2TX Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chloroquine + Tropisetron DC40UVJ Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cilastatin + Tropisetron DCSS7A9 Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cilostazol + Tropisetron DCU0N3Z Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ciprofibrate + Tropisetron DCUQZSB Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diphenidol + Tropisetron DCN388U Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxorubicin + Tropisetron DCWYLQQ Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + Tropisetron DCF3AHY Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GINKGOLIDE A + Tropisetron DCJ8JBN GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Tropisetron DCLTV0M Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + Tropisetron DCX61ZW Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Tropisetron DCXGB6Q Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Tropisetron DCKH0WV Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitrosoglutathione + Tropisetron DCKF5CV Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Tropisetron DCLKMFO Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Tropisetron DCOXFG2 Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Rufinamide + Tropisetron DCU8WM0 Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + Tropisetron DC3HEJF Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triapine + Tropisetron DCF7LUF Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triflupromazine + Tropisetron DCZIRN7 Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Ribavirin-TP DC9GPXJ Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Triiodothyronine DCKQRIB Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Acetazolamide DCWAMTM Acetazolamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Aliskiren DCG2C8C Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Dantrolene DCKPXU2 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Ruxolitinib DCZLAPF Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
Tropisetron + Epinephrine DCVC1W4 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + PMID28460551-Compound-2 DCS2S4P PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Tacrine DCKZRDS Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Dihydroergotamine DCV19S0 Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Vinblastine DCN60GR Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Everolimus DC6YIAQ Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + IT-141 DCOIMD7 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Pamidronate DCVQYBW Pamidronate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Metyrosine DC5H952 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Efavirenz DCS18SG Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Testosterone cypionate DC0HXZX Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Guanfacine DC8FOH8 Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Emetine DCW0TWF Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Chlorzoxazone DC7JE5X Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Memantine DCLYJ6G Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Docetaxel DC9MG75 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Pentamidine DCIVGMO Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Lubiprostone DCC853L Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Tamoxifen DCFV3GY Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Allopurinol DCTIPDK Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Idarubicin DCZXYGD Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Imatinib DCCLYJ7 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Darunavir DCJKBAM Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Trimethobenzamide DCQE3HV Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Brincidofovir DCUYTQG Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Desoxycorticosterone pivalate DCKR6JE Desoxycorticosterone pivalate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Loperamide DC60ON5 Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Spironolactone DCEYTV7 Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Cisatracurium DCNR1R8 Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Vorinostat DCZWYWJ Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Aciclovir DCHM31F Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Acetohydroxamic Acid DCQPYWA Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Cytarabine DC87IHG Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 65 DrugCom(s)
3 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Risperidone + Tropisetron DCI68V9 Risperidone Smoking Cessation [4]
Tropisetron + Acetaminophen DC262CM Acetaminophen Analgesia [5]
Dexamethasone + Tropisetron DCOQYDC Dexamethasone Cervical Cancer [6]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 260).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT00435370) Effectiveness of Tropisetron Plus Risperidone for Improving Cognitive and Perceptual Disturbances in Schizophrenia
5 ClinicalTrials.gov (NCT00970450) The Central Analgesic Effects of Paracetamol on Serotonergic Pathways
6 ClinicalTrials.gov (NCT05564286) Triple Antiemetic Regimen for Chemoradiotherapy in Cervical Cancer or Nasopharyngeal Cancer