Details of the Drug Combinations

General Information of This Drug (ID: DMOZEW9)

Drug Name

PD-0173955 DMOZEW9

Synonyms

PD-17395

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Nilotinib + PD-0173955	DCOED7N	Nilotinib	Hepatoblastoma (Cell Line: HB3)	[2]
PD-0173955 + Piperaquine	DC3W8Q4	Piperaquine	DD2 (Cell Line: DD2)	[3]
PD-0173955 + Ruxolitinib	DCWR1XM	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
PD-0173955 + GSK2126458	DCMMTIG	GSK2126458	Hepatoblastoma (Cell Line: HB3)	[2]
PD-0173955 + Chloroquine	DCBZZIM	Chloroquine	Hepatoblastoma (Cell Line: HB3)	[2]
PD-0173955 + Piperaquine	DC0964D	Piperaquine	Hepatoblastoma (Cell Line: HB3)	[2]
Torin 1 + PD-0173955	DCBUO5G	Torin 1	DD2 (Cell Line: DD2)	[3]
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⏷ Show the Full List of 7 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5699).
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.