Details of the Drug Combinations

General Information of This Drug (ID: DMPDYFR)

• Drug Name: Cefazolin (DMPDYFR)
• Synonyms: CEZ; Cefamezin; Cefamezine; Cefazolina; Cefazoline; Cefazolinum; Cephamezine; Cephazolidin; Cephazolin; Cephazoline; Elzogram; Cephazolin Sodium; Ancef (TN); Cefacidal (TN); Cefamezin (TN); Cefazolin (USP); Cefazolin [USAN:INN]; Cefazolin(usp); Cefazolina [INN-Spanish]; Cefazoline [INN-French]; Cefazolinum [INN-Latin]; Cefrina (TN); Elzogram (TN); Faxilen (TN); Gramaxin (TN); Kefazol (TN); Kefol (TN); Kefzol (TN); Kefzolan (TN); Kezolin (TN); Novaporin (TN); Zolicef (TN); (6R, 7R)-3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[1H-tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R-trans)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)-amino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-7beta-[(1H-tetrazol-1-ylacetyl)amino]-3,4-didehydrocepham-4-carboxylic acid; 7-(1-(1H-)-Tetrazolylacetamido)-3-(2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl)delta3-cephem-4-carboxylic acid

Indication

Bacteremia; ICD 11: 1A73; Status: Approved [1]; Bacterial infection; ICD 11: 1A00-1C4Z; Status: Approved [2]; Cholangitis; ICD 11: N.A.; Status: Approved [1]; Staphylococcal pneumonia; ICD 11: N.A.; Status: Approved [1]

• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

14 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Cefazolin + Azithromycin	DCJH5NV	Azithromycin	Endometritis	[3]
Cefazolin + Metronidazole	DCJWP2V	Metronidazole	Colostomy	[4]
Cefazolin + Azithromycin	DC2U21G	Azithromycin	Obesity	[5]
Clarithromycin + Cefazolin	DCMFEZ4	Clarithromycin	Preterm Premature Rupture of Membrane	[6]
Doxycycline + Cefazolin	DC2GG7Y	Doxycycline	Osteoarthritis	[7]
Framycetin + Cefazolin	DCLDLH4	Framycetin	Colostomy	[4]
Vancomycin + Cefazolin	DC5Y73O	Vancomycin	Thoracic Surgery	[8]
Amikacin + Cefazolin	DCNU2DA	Amikacin	Nosocomial Neonatal Sepsis	[9]
Cephalexin + Cefazolin	DC7N7ZR	Cephalexin	Surgical Site Infection	[10]
Cephalexin + Cefazolin	DCDBRLB	Cephalexin	Fractures, Open	[11]
Clindamycin + Cefazolin	DC17GNA	Clindamycin	Supracondylar Humerus Fracture	[12]
Clindamycin + Cefazolin	DCVPHSM	Clindamycin	Burn	[13]
Lidocaine + Cefazolin	DC8FV2P	Lidocaine	Vitreoretinal Surgery	[14]
Vancomycin + Cefazolin	DCQGT1X	Vancomycin	Surgical Site Infections	[15]

References

• [1] Cefazolin FDA Label
• [2] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 065244.
• [3] ClinicalTrials.gov (NCT01721616) Comparison Study of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis
• [4] ClinicalTrials.gov (NCT03593252) Bowel Preparation in Elective Pediatric Colorectal Surgery
• [5] ClinicalTrials.gov (NCT03801252) Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term
• [6] ClinicalTrials.gov (NCT01503606) Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane
• [7] ClinicalTrials.gov (NCT03115177) Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?
• [8] ClinicalTrials.gov (NCT02285140) Prevention of Infections in Cardiac Surgery
• [9] ClinicalTrials.gov (NCT01867138) Neonatal Suspected Sepsis Treated With Cefazolin or Vancomycin
• [10] ClinicalTrials.gov (NCT04834310) Postoperative Antibiotics Following Primary and Secondary Breast Augmentation
• [11] ClinicalTrials.gov (NCT06055712) Antibiotic Prophylaxis in Pediatric Open Fractures
• [12] ClinicalTrials.gov (NCT03261830) Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS)
• [13] ClinicalTrials.gov (NCT04516148) A Randomized, Controlled Trial of the Effectiveness of Perioperative Antibiotics for Reduction of Burn Wound Bacterial Concentration Following Grafting
• [14] ClinicalTrials.gov (NCT02324166) Cefazolin-Lidocaine Combination Solution to Reduce Antibiotic Pain
• [15] ClinicalTrials.gov (NCT03402945) Prevention of Infections in Cardiac Surgery (PICS) Prevena Study