Details of the Drug Combinations

General Information of This Drug (ID: DMPU2WX)

• Drug Name: Omacetaxine mepesuccinate (DMPU2WX)
• Synonyms: Synribo (TN)

Indication

Adult acute monocytic leukemia; ICD 11: N.A.; Status: Approved [1]; Chronic myelogenous leukaemia; ICD 11: 2A20.0; Status: Approved [1]; Chronic myeloid leukaemia; ICD 11: 2A20; Status: Approved [2]; Leukemia; ICD 11: N.A.; Status: Approved [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

62 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Alvespimycin hydrochloride + Omacetaxine mepesuccinate	DCJED06	Alvespimycin hydrochloride	DD2 (Cell Line: DD2)	[3]
Artemether + Omacetaxine mepesuccinate	DCTHZI4	Artemether	DD2 (Cell Line: DD2)	[3]
Artemisinin + Omacetaxine mepesuccinate	DCQH6LL	Artemisinin	DD2 (Cell Line: DD2)	[3]
Artemisinin + Omacetaxine mepesuccinate	DCXM83L	Artemisinin	Hepatoblastoma (Cell Line: HB3)	[3]
Diltiazem + Omacetaxine mepesuccinate	DCIMJPF	Diltiazem	DD2 (Cell Line: DD2)	[3]
Diltiazem + Omacetaxine mepesuccinate	DC6B5PM	Diltiazem	Hepatoblastoma (Cell Line: HB3)	[4]
Epothilone B + Omacetaxine mepesuccinate	DCQYJA7	Epothilone B	Hepatoblastoma (Cell Line: HB3)	[4]
Lumefantrine + Omacetaxine mepesuccinate	DCXKKNB	Lumefantrine	DD2 (Cell Line: DD2)	[3]
Lumefantrine + Omacetaxine mepesuccinate	DCBE6W0	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
Mefloquine + Omacetaxine mepesuccinate	DCJY0XJ	Mefloquine	DD2 (Cell Line: DD2)	[3]
Mefloquine + Omacetaxine mepesuccinate	DCDJJ89	Mefloquine	Hepatoblastoma (Cell Line: HB3)	[3]
Miconazole + Omacetaxine mepesuccinate	DCB9VGZ	Miconazole	DD2 (Cell Line: DD2)	[3]
Miconazole + Omacetaxine mepesuccinate	DCL8V0R	Miconazole	Hepatoblastoma (Cell Line: HB3)	[4]
MK-4815 + Omacetaxine mepesuccinate	DCEUUIX	MK-4815	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + DZNep	DC197UP	DZNep	Lymphoid neoplasm (Cell Line: Mak)	[3]
Omacetaxine mepesuccinate + OZ277	DCM6EZX	OZ277	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Lumefantrine	DCROSTP	Lumefantrine	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + T-3.5	DCTDLWZ	T-3.5	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Panobinostat	DCFXSX6	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Omacetaxine mepesuccinate + Diltiazem	DCI07KO	Diltiazem	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Docetaxel	DCJOJ2E	Docetaxel	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Sarpogrelate	DCIFID4	Sarpogrelate	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + RG6046	DCDWOWR	RG6046	Lymphoid neoplasm (Cell Line: Mak)	[3]
Omacetaxine mepesuccinate + Apilimod	DC1JJWZ	Apilimod	Lymphoid neoplasm (Cell Line: Mak)	[3]
Omacetaxine mepesuccinate + Idarubicin	DCFJYOV	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
Omacetaxine mepesuccinate + Epothilone B	DCHUBZ0	Epothilone B	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Sunitinib malate	DCC3LG6	Sunitinib malate	Hepatocellular carcinoma (Cell Line: Huh-7)	[3]
Omacetaxine mepesuccinate + Sunitinib malate	DC5CX3C	Sunitinib malate	Lymphoid neoplasm (Cell Line: Mak)	[3]
Omacetaxine mepesuccinate + Artemisinin	DC70ZSJ	Artemisinin	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Doxepin	DCZ7IDU	Doxepin	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Miconazole	DC76MCW	Miconazole	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Omacetaxine mepesuccinate	DCURDVJ	Omacetaxine mepesuccinate	Lymphoid neoplasm (Cell Line: Mak)	[3]
Omacetaxine mepesuccinate + Quinine	DC6PIJ7	Quinine	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + MK-4815	DCC6JKG	MK-4815	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Bifemelane	DCQMMSO	Bifemelane	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Mefloquine	DC7PHFF	Mefloquine	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Primaquine	DCYHLZI	Primaquine	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Atovaquone	DCNLSJW	Atovaquone	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + OZ277	DC6MB1T	OZ277	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Ruxolitinib	DCPLMX8	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[4]
Omacetaxine mepesuccinate + Lumefantrine	DCG4U36	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + T-3.5	DC3HE5A	T-3.5	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Alvespimycin hydrochloride	DCD6GKF	Alvespimycin hydrochloride	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Verapamil	DCUTDR3	Verapamil	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Diltiazem	DCHG3XU	Diltiazem	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Thiolactomycin	DCDN5OX	Thiolactomycin	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Sarpogrelate	DCUAPX1	Sarpogrelate	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Epothilone B	DCXHPR3	Epothilone B	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Bardoxolone methyl	DCGFV07	Bardoxolone methyl	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Artemisinin	DC68CYR	Artemisinin	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Miconazole	DCW85BC	Miconazole	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + MK-4815	DCG09SV	MK-4815	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Ritonavir	DCCRW3I	Ritonavir	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Pyronaridine	DC96Z7O	Pyronaridine	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Mefloquine	DCBQ31L	Mefloquine	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Atovaquone	DCWMFGF	Atovaquone	Hepatoblastoma (Cell Line: HB3)	[4]
Piperaquine + Omacetaxine mepesuccinate	DCZG3L1	Piperaquine	Hepatoblastoma (Cell Line: HB3)	[4]
Sarpogrelate + Omacetaxine mepesuccinate	DCYSPVE	Sarpogrelate	Hepatoblastoma (Cell Line: HB3)	[4]
Sorafenib + Omacetaxine mepesuccinate	DCTK2LJ	Sorafenib	DD2 (Cell Line: DD2)	[3]
Sorafenib + Omacetaxine mepesuccinate	DCVYS9Q	Sorafenib	Hepatoblastoma (Cell Line: HB3)	[3]
Thiolactomycin + Omacetaxine mepesuccinate	DCMR8M5	Thiolactomycin	Hepatoblastoma (Cell Line: HB3)	[4]
ZM-447439 + Omacetaxine mepesuccinate	DCDAFQ5	ZM-447439	DD2 (Cell Line: DD2)	[3]

7 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Omacetaxine mepesuccinate + Cytarabine	DC2FU5B	Cytarabine	Chronic Myelogenous Leukemia, BCR-ABL1 Positive	[5]
Omacetaxine mepesuccinate + Decitabine	DC7X88R	Decitabine	Leukemia	[6]
Omacetaxine mepesuccinate + Azacitidine	DC9KSIW	Azacitidine	High Grade Myelodysplastic Syndromes	[7]
Venetoclax + Omacetaxine mepesuccinate	DC23R8P	Venetoclax	Hematopoietic and Lymphoid Cell Neoplasm	[8]
Venetoclax + Omacetaxine mepesuccinate	DCGGYCF	Venetoclax	Relapsed or Refractory Hematologic Malignancies	[9]
Omacetaxine mepesuccinate + Decitabine	DCBLK4G	Decitabine	Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome	[10]
Venetoclax + Omacetaxine mepesuccinate	DCIR4BI	Venetoclax	Acute Myeloid Leukemia	[11]

References

• [1] Omacetaxine mepesuccinate FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7454).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT00003694) Homoharringtonine Plus Low-Dose Cytarabine in Treating Patients With Newly Diagnosed Chronic Myelogenous Leukemia in Chronic Phase
• [6] ClinicalTrials.gov (NCT02141477) Omacetaxine and Decitabine in Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndrome (MDS)
• [7] ClinicalTrials.gov (NCT03564873) Omacetaxine + Azacitidine in Untreated Patients With High Grade MDS
• [8] ClinicalTrials.gov (NCT04874194) Omacetaxine and Venetoclax for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Harboring Mutant RUNX1
• [9] ClinicalTrials.gov (NCT04926285) Safety and Efficacy of Venetoclax With Escalating Doses of Omacetaxine in Patients With Acute Myeloid Leukemia Safety and Efficacy of Venetoclax With Escalating Doses of Omacetaxine in Patients With Acute Myeloid Leukemia (AML)
• [10] ClinicalTrials.gov (NCT02029417) Omacetaxine Mepesuccinate, Cytarabine, and Decitabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
• [11] ClinicalTrials.gov (NCT05805098) Venetoclax Combined With Homoharringtonine and Cytarabine in Induction for AML