Details of the Drug Combinations

General Information of This Drug (ID: DMPWHU6)

Drug Name

V81444 DMPWHU6

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Phase 1/2	[1]
Advanced cancer	2A00-2F9Z	Phase 1	[2]
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Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
V81444 + Panobinostat	DC6KDK4	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
V81444 + Ruxolitinib	DCIFECF	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[4]
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References

1	ClinicalTrials.gov (NCT02253745) Safety, Tolerability, PK & Efficacy of V81444 in Volunteers With Attention Deficit/ Hyperactivity Disorder (ADHD). U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
4	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976