Details of the Drug Combinations

General Information of This Drug (ID: DMPZI3Q)

Drug Name
Ketoconazole   DMPZI3Q
Synonyms
KCZ; KTZ; K 1003; R 41400; R41400; KS-1205; KW-1414; Perkhotal (TN); R 41,400; R-41400; R41,400; Ketoconazole [USAN:INN:BAN:JAN]; Nizoral, Extina, Xolegel, Kuric, Ketoconazole; Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-piperazine; Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; CIS-1-ACETYL-4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)PIPERAZINE; (+-)-cis-1-Acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine; (+/-)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine; (+/-)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone; 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
Indication
Disease Entry ICD 11 Status REF
Blastomycosis 1F22 Approved [1]
Chromomycosis N.A. Approved [1]
Coccidioidomycosis 1F25 Approved [1]
Cutaneous candidiasis 1F23.14 Approved [1]
Fungal infection 1F29-1F2F Approved [2]
Histoplasmosis N.A. Approved [1]
Invasive candidiasis 1F23 Approved [1]
Mycoses 1F2Z Approved [1]
Oral candidiasis 1F23.0 Approved [1]
Paracoccidioidomycosis N.A. Approved [1]
Pityriasis simplex N.A. Approved [1]
Prostate adenocarcinoma N.A. Approved [1]
Tinea corporis 1F28.Y Approved [1]
Tinea cruris 1F28.3 Approved [1]
Tinea versicolor 1F2D.0 Approved [1]
Tinea pedis 1F28.2 Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antifungal Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Ketoconazole + Idarubicin DCPRMTT Idarubicin Glioblastoma? (Cell Line: T98G) [3]
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14 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-263 + Ketoconazole DCUV43Q ABT-263 Lymphoma [4]
Avanafil + Ketoconazole DCZ94TJ Avanafil Erectile Dysfunction [5]
Casopitant + Ketoconazole DCAF1NV Casopitant Nausea and Vomiting, Chemotherapy-Induced [6]
Darexaban maleate + Ketoconazole DCAYQZN Darexaban maleate Pharmacokinetics of Darexaban and Metabolites [7]
Dexamethasone + Ketoconazole DC9AEDQ Dexamethasone Prostate Cancer [8]
Docetaxel + Ketoconazole DCBH0CB Docetaxel Solid Tumors [9]
Fluvoxamine + Ketoconazole DCW83WS Fluvoxamine Pharmacology, Clinical [10]
Hydrocortisone + Ketoconazole DCKXM7K Hydrocortisone Prostate Cancer [11]
Ketoconazole + Colchicine DC0AXQ7 Colchicine Pharmacokinetics [12]
Ketoconazole + Romidepsin DC6KLH4 Romidepsin Hematologic Malignancy [13]
Ketoconazole + Pomalidomide DCJNL3L Pomalidomide Pharmacology, Clinical [10]
Ketoconazole + Isavuconazole DCL07HC Isavuconazole Pharmacokinetics of Isavuconazole [14]
Naloxegol + Ketoconazole DCR1TYB Naloxegol Bioavailability [15]
Venetoclax + Ketoconazole DC0FE2V Venetoclax Non-Hodgkin's Lymphoma [16]
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⏷ Show the Full List of 14 DrugCom(s)

References

1 Ketoconazole FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2568).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT01021358) A Study to Assess the Effect of Ketoconazole on the Metabolism of ABT-263 (Navitoclax).
5 ClinicalTrials.gov (NCT00770042) To Evaluate The Effect Of Ketoconazole, Ritonavir and Erythromycin on the Safety and Pharmacokinetics of Avanafil
6 ClinicalTrials.gov (NCT00404378) Study Of Healthy Subjects To Assess The Effect Of Ketoconazole And The Way The Body Will React To Casopitant [GW679769]
7 ClinicalTrials.gov (NCT01405989) To Evaluate if Multiple Doses of Ketoconazole Change the Blood Concentration of YM150 (Darexaban)
8 ClinicalTrials.gov (NCT01036594) Ketoconazole and Dexamethasone in Prostate Cancer
9 ClinicalTrials.gov (NCT00697437) Effect of Ketoconazole Inhibition of CYP3A on Urinary Excretion of Docetaxel
10 ClinicalTrials.gov (NCT01707407) A Phase 1 Open-Label Study to Evaluate the Effect of CYP450 and P-gp Inhibition and Induction on the Pharmacokinetics of Pomalidomide (CC-4047) in Healthy Male Subjects
11 ClinicalTrials.gov (NCT00895310) Use of Low Dose Ketoconazole in Prostate Cancer That Does Not Respond to Hormone Therapy and Prior Chemotherapy
12 ClinicalTrials.gov (NCT00983216) Drug-Drug Interaction Study Between Colchicine and Ketoconazole
13 ClinicalTrials.gov (NCT01324310) Influence of Ketoconazole on the Pharmacokinetics of Romidepsin in Patients With Advanced Cancer
14 ClinicalTrials.gov (NCT01657838) Drug Interaction Study of the Effect of Ketoconazole at Steady State on the Pharmacokinetics of a Single Dose of Isavuconazole in Healthy Adult Subjects
15 ClinicalTrials.gov (NCT01520896) Study in Healthy Volunteers to Investigate the Effects of Ketoconazole on the Pharmacokinetics of NKTR-118
16 ClinicalTrials.gov (NCT01969669) A Study to Assess the Effect of Ketoconazole on the Metabolism of ABT-199