Details of the Drug Combinations

General Information of This Drug (ID: DMQPEA7)

Drug Name

PRT-060318 DMQPEA7

Synonyms

PRT-318; Syk inhibitor (oral, heparin-induced thrombocytopenia), Portola

Indication

Disease Entry	ICD 11	Status	REF
Thrombosis	DB61-GB90	Investigative	[1]
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Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
PRT-060318 + Panobinostat	DCML8AP	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
PRT-060318 + Mitomycin	DCA952R	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2230).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.